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Robert J. Boissy, Ph.D.
Education
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1994
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Ph.D., Biochemistry & Molecular Biology, The University of
British Columbia
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Research Interests
- The bioinformatics and
computational biology of host immune responses, infectious agents, and
cancer
- The design and implementation
of very large relational databases and analysis services
- The integration of very large
relational databases and analysis services, and exposure of their
functionality, using web services
- Data analysis and
visualization using software tools for statistics and discrete
mathematics
- Structured Query Fragment
Analysis (SQF analysis), and its use for the discovery of molecular diagnostics
for early-stage cancer detection, cancer treatment efficacy monitoring,
and the detection of otherwise undetectable infectious agents
- Robotics and computer-assisted
laboratory automation. The development of solid-phase technologies for
the manipulation and analysis of polynucleotides
- The chemistry of
polynucleotides and their constituent monomers, and the analytical
chemistry of polynucleotide detection and characterization
Current Projects
- Assembly and annotation of
genomic DNA sequence data obtained from bacterial clinical isolates
- Assembly and annotation of
data generated by next-generation DNA sequencing technologies
- Distributed computing
infrastructure support for bioinformatics and computational biology
Professional Memberships
Member, American Association for the Advancement of Science (AAAS)
Member, Association for Computing Machinery (ACM)
Member, Institute of Electrical and Electronics Engineers (IEEE)
Member, IEEE Computer Society
Member, International Society for Computational Biology (ISCB)
Honors & Awards
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1996-2001
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Visiting Fellow, NIEHS, NIH
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1988-1990
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Medical Research Council of Canada Studentship
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1986-1988
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University of British Columbia Graduate Fellowship
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1984
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Violet & Blythe Eagles Undergraduate Prize in Biochemistry
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Publications
Boissy RJ, Astell CR. 1985. An Escherichia coli recBCsbcBrecF host permits
the deletion-resistant propagation of plasmid clones containing the 5í-terminal
palindrome of minute virus of mice. Gene 35:179-185.
Kay RJ, Boissy RJ, Russnak RH, Candido EPM. 1986. Efficient transcription
of a Caenorhabditis elegans heat shock gene pair in mouse fibroblasts is
dependent on multiple promoter elements which can function bidirectionally.
Mol Cell Biol 6:3134-3143.
Boissy RJ. 1994. Some new approaches to conventional
methods for the study of protein-DNA interactions. Ph.D. Thesis, The University of British Columbia.
Millikan RC, Pittman GS, Tse CK, Duell E, Newman B, Savitz D, Moorman PG,
Boissy RJ, Bell DA. 1998. Catechol O-methyl transferase and breast cancer
risk. Carcinogenesis 19:1943-1947.
Katoh T, Kaneko S, Boissy R, Watson M, Ikemura K, Bell DA. 1998. A pilot
study testing the association between N-acetyltransferases 1 and 2 and risk
of oral squamous cell carcinoma in Japanese people. Carcinogenesis
19:1803-1807.
Katoh T, Boissy R, Nagata N, Kitagawa K, Kuroda Y, Itoh H, Kawamoto T,
Bell DA. 2000. Inherited polymorphism in the N-acetyltransferase 1 (NAT1) and
2 (NAT2) gene(s) and susceptibility to gastric and colorectal adenocarcinoma.
Intl J Cancer 85:46-49.
Boissy R, Watson MA, Umbach SD, Deakin M, Elder J, Strange RC, Bell DA.
2000. A preliminary study investigating the role of NAT1 and NAT2
polymorphisms in gastric adenocarcinoma. Intl J Cancer 87:507-511.
Lasken RS, Raghunathan A, Kvist T, Ishoy T, Westermann P, Ahring BK,
Bossiy R. 2005. Multiple displacement amplification from
single bacterial cells. In: Whole Genome Amplification. Hughes, S, & Lasken, R.S., Eds., Scion
Publishing Ltd., Blxham, UK.
Carreon T, Ruder AM, Schulte PA, Hayes RB,
Rothman N, Waters M, Grant DJ, Boissy R, Bell DA, Kadlubar FF, Hemstreet GP,
Yin S, LeMasters GK. 2006. NAT2 slow acetylation and bladder cancer in
workers exposed to benzidine. Int J Cancer 118:161-168.
Hogg JS, Hu FZ, Janto B, Boissy R, Hayes J, Keefe R, Post JC, Ehrlich
GD. 2007. Characterization and modeling of the Haemophilus influenzae
core and supra-genome supragenome based on the complete genomic sequences of
Rd and 12 clinical nontypeable strains.
Genome Biology 8(6):R103.
Mußmann M, Hu FZ, Richter M, de Beer D, Preisler A, Jørgensen BB, Glöckner
FO, Amann R, Koopman WJH, Janto B, Hogg JS, Boissy R, Lasken RS, Stoodley P,
Ehrlich GD. 2007. Insights into the
genome of large sulphur bacteria revealed by analysis of single
filaments. PLoS Biology 5(9):e230.
Hiller NL, Janto B, Hogg JS, Boissy
R, Yu S, Powell E, Keefe R, Ehrlich NE, Shen K, Hayes J, Barbadora K, Klimke
W, Dernovoy D, Tatusova T, Parkhill J, Bentley SD, Post JC, Ehrlich GD, Hu
FZ. 2007. Comparative genomic
analyses of seventeen Streptococcus pneumoniae strains:
Insights into the pneumococcal supragenome 2. J Bacteriol 189(22):8186-8195.
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