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Joseph Donfack, Ph.D.
Education
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1990
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B.A., University of Yaoundé (Cameroon)
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1992
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M.S., University of Yaoundé (Cameroon)
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1997
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Ph.D, University of Yaoundé (Cameroon)
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Research Interests
- Identify genes that influence
both quantitative and qualitative traits
- Understand how alleles in
these candidate loci influence the function and the disease phenotypes
- Understand their evolutionary
history
Current Projects
My current ongoing research project has focused on Severe Pediatric
Gastroesophageal Reflux (GER). Using genome-wide screen approach, our
laboratory identified a genetic locus that cosegregates with severe GER in
Caucasian families with multiple affected members at 6 cM susceptibility
region on human chromosome 13q14. This region is currently the focus of fine
mapping using linkage disequilibrium mapping and positional cloning.
Another project of interest but not yet initiated focused on Recurrent
Respiratory Papillomatosis (RRP). We would like to perform a genome scan
approach using short tandem repeat polymorphisms (STRPs) and single
nucleotide polymorphisms (SNPs) to identify RRP susceptibility loci.
Honors And Awards
World Health Organization (W.H.O.), 1997
Edna McConnel Clark Foundation (NIAID, NIH), 1996
The American Red Cross, 1996
The European Community, 1993
The Jackson Laboratory Fellowship, 2000
Publications
Donfack J, Buchinsky FJ, Derkay CS, Steinberg BM, Choi SS, Conley SF, Myer
CM III, McClay JE, Campisi P, Hu FZ, Preston RA, Abramson AL, Ehrlich GD,
Post JC. Four mutations in
epidermodysplasia verruciformis 1 (EVER1) gene are not contributors to
susceptibility in RRP. Int J Pedatr Otorhinolaryngol 70:1235-1240,
2006.
Donfack J, Buchinsky FJ, Post JC, Ehrlich GD. Human susceptibility to viral infection: The search for HIV-protective alleles
among Africans by means of genome-wide studies. AIDS Res Hum Retroviruses 22;10:925-930, 2006.
Sherwood ML, Buchinsky FJ, Quigley MR, Donfack J, Choi SS, Conley SF,
Derkay CS, Myer CM III, Ehrlich GD, Post JC.
Unique challenges of obtaining regulatory approval for a multicenter
protocol to study the genetics of RRP and suggested remedies. Otolaryngol Head Neck Surg
135:189-196, 2006.
Hu FZ, Donfack J, Ahmed A, Dopico R, Johnson S, Post JC, Ehrlich GD,
Preston RA. Fine mapping a gene for
pediatric gastroesophageal reflux on human chromosome 13q14. Hum Genet 114;6:562-572, 2004.
Buchinsky FJ, Derkay CS, Leal SM, Donfack J, Ehrlich GD, Post JC. Multicenter initiative seeking crtical
genes in respiratory papillomatosis. Laryngoscope
114:349-357, 2004.
Donfack J, Kogut P, Forsythe S, Solway J, Ober C. Sequence variation in
the promoter region of the cholinergic receptor muscarinic 3 gene and asthma
and atopy. J Allergy Clin Immunol
March;111(3):527-532, 2003.
Frisse L, Hudson RR, Bartoszewicz A, Wall JD, Donfack J, Di Rienzo A. gene
conversion and different population histories may explain the contrast
between polymorphism and linkage disequilibrium levels. Am J Hum Genet Oct;69(4):831-43, 2001.
Donfack J., Tsalenko A., Hoki DM, Parry R., Solway J., Lester LC, Ober C.
HLA HLA-DRB1*01 alleles are associated with sensitization to cockroach
allergens. J Allergy Clin Immunol May;105(5):960-966, 2000.
Donfack J, Ngu J. L., Lando G., Zimmerman P. A., Nutman T. B., Ekobo S. A.
HLA class II alleles and clinical Onchocerciasis in three different ethnic
population in Cameroon. Bulletin de Société de Pathologie Exotique May;92(2): 85-90, 1999.
Lando G, Simo G, Tatchum G, Donfack J, Djoha S, Tume C. Proteolytic
activity of Onchocerca volvulus Crude Extract. Bulletin de Société de
Pathologie Exotique
Feb;92(1):9-12, 1999.
Ngu JL, Nkenfou C, Capuli E, McMoli TE,
Perler F, Mbwagbor J, Tume C, Nlatte OB, Donfack J, Asonganyi T. Novel,
sensitive and low-cost diagnostic tests for 'river blindness'--detection of
specific antigens in tears, urine and dermal fluid. Trop Med Int Health May;3(5):339-48, 1998.
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