|
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Garth D. Ehrlich, Ph.D
| Name |
|
Garth D. Ehrlich, Ph.D. |
| Title |
|
Executive Director, Center for Genomic Sciences Allegheny-Singer Research Institute |
| Business Address |
|
320 East North Avenue Pittsburgh, PA 15212-4772 |
| Office |
|
(412) 359-4228 |
| Assistant |
|
(412) 359-8169 |
| Fax |
|
(412) 359-6995 |
| Email |
|
gehrlich@wpahs.org |
Professional Interests
- Molecular Pathogenesis of Chronic Infectious Diseases
- Human Disease Gene Mapping, Cloning, and Modeling
- Applications of the polymerase chain reaction to clinical diagnostics, epidemiology, and human genetics
- Molecular Biology of Scarless Wound Healing
- Comparative Expressome Analyses
- Human Retroviral Pathogenesis
Academic and Administrative Positions at MCP-Hahnemann University/Allegheny General Hospital/Allegheny Singer Research Institute (10/97-Date)
| 07/01-Date |
|
Research Advisor, GI fellowship program, Allegheny General Hospital |
| 06/01-Date |
|
Professor of Microbiology and Immunology (primary appointment) MCP Hahnemann University School of Mediicne |
| 08/98-Date |
|
Professor of Surgery MCP-Hahnemann University School of Medicine. (appointment still in process) |
| 07/98-Date |
|
Vice Chairman, Department of Human Genetics |
| 07/98-Date |
|
Professor of Human Genetics, MCP-Hahnemann University School of Medicine |
| 10/97-Date |
|
Executive Director, Center for Genomic Sciences, Allegheny General Hospital/Allegheny Singer Research Institute |
| 10/97-Date |
|
Professor of Otolaryngology, MCP-Hahnemann University School of Medicine |
| 01/98-Date |
|
Director of Research, Department of Otolaryngology, MCP-Hahnemann University School of Medicine |
| 12/97-7/98 |
|
Associate Director, Allegheny Cancer Center, MCP-Hahnemann University School of Medicine (center closed) |
Honorary and Adjunct Academic Appointments
| 07/99-Date |
|
Honorary Professor of Medical Genetics, West China University of the Medical Sciences, Chengdu, Sichuan, China |
| 01/01-Date |
|
Adjunct Professor of Biomedical &Health Engineering, Carnegie Mellon University, Pittsburgh, PA. |
| 10/01-Date |
|
Honorary Professor, Santou University School of Medicine, Santou, Guan Zhou, China |
Academic and Administrative Positions at the University of Pittsburgh (6/90-10/97)
| 1/96-10/97 |
|
Associate Professor of Pathology (with Tenure), University of Pittsburgh, School of Medicine |
| 6/96-10/97 |
|
Executive Director, Center for Genomic Sciences, University of Pittsburgh and Children's Hospital of Pittsburgh |
| 12/93-10/97 |
|
Chief, Virology, Microbiology and Infectious Disease Section, Molecular Diagnostics Division, Department of Pathology |
| 5/91-10/97 |
|
Member, Graduate Faculty, University of Pittsburgh, School of Medicine |
| 1/92-10/97 |
|
Adjunct Member, Central Blood Bank of Pittsburgh |
| 1/96-10/97 |
|
Associate Professor of Otolaryngology, University of Pittsburgh, School of Medicine |
| 1/96-10/97 |
|
Associate Professor of Infectious Disease and Microbiology, Graduate School of Public Health |
| 6/90-6/91 |
|
Head, Molecular Diagnostics Unit, Department of Pathology |
| 6/90-10/97 |
|
Clinical Director, Central Testing Facility, Molecular Diagnostics Division, University of Pittsburgh Medical Center |
| 7/91-10/97 |
|
Director, Core PCR Facility, Department of Pathology |
| 7/95-8/95 |
|
Acting Director, Molecular Diagnostics Division |
| 6/90-12/95 |
|
Assistant Professor of Pathology, University of Pittsburgh, School of Medicine |
| 6/90-12/95 |
|
Assistant Professor of Infectious Diseases & Microbiology, Graduate School of Public Health, University of Pittsburgh |
| 7/92-12/95 |
|
Assistant Professor, Department of Otolaryngology, University of Pittsburgh Department of Pediatric Otolaryngology, Children's Hospital of Pittsburgh |
Previous Employment
| 04/89-06/90 |
|
Research Assistant Professor, Department of Medicine, SUNY Health Science Center at Syracuse and Principal Research Scientist SUNY Research Foundation |
| 07/88-04/89 |
|
Research Instructor, Department of Medicine, SUNY Health Science Center at Syracuse |
| 07/86-06/88 |
|
Technical Specialist II, SUNY Research Foundation at SUNY Health Science Center at Syracuse
- Development of PCR as a diagnostic tool in retrovirology
- Evaluation of the effect of retroviral infections on chromosomal methylation patterns
|
| 05/84-07/86 |
|
Technical Specialist I, SUNY HSC at Syracuse
- Detection, epidemiology and spectrum of disease associated with HIV, HTLV-I and II
- Correlation of HTLV-I tax gene expression with disease
|
| 07/83-04/84 |
|
Research Scientist B, for Bristol Myers Industrial Division, Genetic Engineering Group
- Purified mRNA from Fusarium oxysporum
- Establish in vitro translation assay for F. oxysporum mRNA
|
| 10/81-07/83 |
|
Research Scientist C, Bristol Myers Industrial Division, Genetic Engineering Group
- Initiated amidohydrolase cloning project
- Studied F. oxysporum growth kinetics vs. regulation of amidohydrolase
|
| 10/81-01/83 |
|
Research Specialist, Syracuse University, Biology Department |
| 03/80-10/81 |
|
Research Microbiologist, Bethesda Research Laboratories Cloning and mutagenesis of genes for amino acid biosynthesis |
| 03/78-02/80 |
|
Self-employed Agri Business |
| 09/75-05/77 |
|
University sponsored tutor in the Biological and Chemical Sciences. Laboratory specimen preparation
|
Current Research Projects
Development of a multi-component theoretical framework for the understanding of chronic bacterial pathogenesis embodying the concepts of bacterial plurality
- The distributed genome hypothesis (2001) and bacterial virulence in chronic infections (genomic plurality, based upon studies in genomic plasticity)
- The biofilm paradigm (1996) of chronic bacterial infections (phenotypic plurality, based upon metabolic [1996] and imaging studies [2002])
- Pathogenesis of otitis media with effusion (1990-2002) (a model of chronic infectious disease)
Understanding the pathophysiological bases of human genetic diseases based upon disease gene identifcation and the development of animal and theoretical models
- Disease gene mapping: a) Crouzon craniofacial dysostosis-completed 1994; b) hereditary pancreatitis-completed 1996; c) diffuse abnormal insertional activity (DAIA)-completed 1996; d) extrodactyly-completed 1999; e) Crohn's disease and ulcerative colitis-QTL identified 1998; f) pediatric gastroesophageal reflux-completed 2000; g) vesicoureteral reflux-ongoing since 1995; h) Dupuytren contracture-ongoing since 1995; i) speech and language acquisition-specimen collection initiated 2000; j) susceptibility to chronic bacterial infections-specimen collection initiated 2001; k) autoimmunity multiple sclerosis-specimen collection initiated 2001; l) external ear formation-animal breeding experiments 2001.
- Disease gene cloning: a) Crouzon syndrome/Jackson Weiss-completed 1995; b) hereditary pancreatitis-completed 1996-1997; c) pediatric GER-ongoing.
3) Disease gene modeling: a) Crouzon syndrome-nude rat-human mutant osteoblast chimeras; b) hereditary pancreatitis-theoretical model based on mutational affects on protein (1996)-experimental support 1998-2001.
Building moving pictures of gene expression using SS-RT-PCR, differential display, and RNA array technologies of normal and patholgoical conditions.
- scarless wound healing (1995-date);
- premature craniosynostosis (1998-date);
- bacterial biofilm formation in the middle ear (both bacterial and mucosal gene expression patterns) (1998-date)
- Barrett's metaplasia (2002);
- Colon cancer metastasis (2001)
Clinical Testing
- PCR-based testing for CMV, HSV, VZV, EBV, Lyme disease, HBV and the human retroviruses
- RT-PCR-based testing for HCV and the human retroviruses
- Detection of infectious agents in upper respiratory infections and otitis media by PCR including: S. pneumoniae, H. influenzae, M. catarrhalis, Bordatella pertussis, influenza virus, parainfluenza virus, rhinovirus, respiratory syncytial virus, and adenovirus.
Clinical Development Projects
- Development of multiplex organ system-based molecular diagnostics.
- upper respiratory viral infections
- upper respiratory bacterial infections
- septic vs. aseptic meningitis (patent application approved)
Consulting
| 11/89-05/90 |
|
University of Pittsburgh |
| 11/89-08/90 |
|
Syracuse Research Corporation |
| 02/90-Date |
|
Teltech, Inc. |
| 08/90-07/91 |
|
EWI |
| 06/91-1993 |
|
RFP-NIH-NIAID-DAIT-91-22 (Rene J. Duquesnoy, Ph.D.) |
| 07/91-1997 |
|
Roche Molecular Systems (informal, limited to materials exchange and comparison of test results) |
| 07/91-06/94 |
|
Kodak, Clinical Products Division, Rochester, New York |
| 01/92-01/95 |
|
Central Blood Bank, Pittsburgh, PA |
| 05/92-3/93 |
|
Smith, Helms, Mulliss & Moore, Raleigh, North Carolina |
| 11/92 |
|
Travelers Insurance Co. |
| 02/93-11/96 |
|
Oncogenetics |
| 08/93-7/95 |
|
TM Technologies |
| 02/95-01/96 |
|
McKnight and Thompson, Houston, TX/ Hotel Six |
| 07/94-11/97 |
|
Children's Hospital, Pittsburgh, PA |
| 08/96-10/97 |
|
Third Wave Technologies (informal, limited to material exchange and comparison of test results) |
| 11/96-9/97 |
|
Impath |
| 01/97 |
|
Boehringer Mannheim |
| 02/97-6/99 |
|
Visible Genetics/Gene Foundry |
| 03/97-03/99 |
|
CL Scientific/ Kaiyuan Bioengineering, Ltd. |
| 01/98-03/99 |
|
Quest Diagnostics/Nichols Institute |
| 01/00-Date |
|
Pfizer (molecular diagnostic support of clinical trials) |
| 02/02-Date |
|
Medtronics (pending) |
| 10/01-Date |
|
Radvault (Scientific Advisory Board member) |
| 03/02-Date |
|
Bacterin (Scientific Advisory Board member)
|
Education
| 07/87-06/88 |
|
Post-Doctoral Fellow-Division of Hematology/Oncology, Department of Medicine, SUNY HSC (Upstate Medical Center) at Syracuse |
| 09/84-08/87 |
|
Ph.D.-Syracuse University-in Biology
- Dissertation title: Correlation of Clinical and Molecular Parameters of Human Retroviral Infections
- Mentors: John Vournakis, Bernard Poiesz, and Judith Foster
|
| 09/74-05/77 |
|
B.A.-Alfred University-Honors in Biology, May 1977 magna cum laude |
Licensure
| 07/26/94-07/26/2002 |
New York State Department of Health, Certificate of Qualification. Laboratory Director: Direct Molecular Detection Techniques, Infectious Agents Code Number: EHRLG1 |
Personal
| Birth Date |
|
July 9, 1956 |
| Health |
|
Excellent |
| Children |
|
Ian S.G. Ehrlich, son DOB 04/09/81; electrical engineering student University of Pittsburgh |
|
|
Nathan E.G. Ehrlich, son DOB 03/21/84; varsity soccer, math major, Taylor Allderdice HS |
| Hobbies |
|
Alpine Skiing, Travel, Mountain Biking, Karaoke, and Magic the Gathering. |
Community Activities
Member-Syracuse City School District's Gifted Education Advisory Board (1989-1990)
Lecturer-on AIDS to Secondary School Children; Science to elementary school children (1989-Date)
Established-the Genomic Sciences Institute for training of high school biology teachers through didactic and hands-on continuing education within a major research facility (2001-Date)
Honors and Awards
- New York State Regents Scholarship 09/73-05/77
- Advanced biology GRE 840 (98th percentile)
- American Chemical Society O Chem exam 56 (99th percentile)
- Departmental Honors (Biology) conferred upon graduation from Alfred University.
- Member Phi Kappa Phi (general scholastic honorary)
- Nominated by Alfred University for the Danforth Fellowship competition
- Awarded honorable mention in the National Science Foundation predoctoral fellowship competition
- Enrolled at University of Chicago with a National Institutes of Health predoctoral Fellowship
- Research Assistant SUNY HSC at Syracuse 04/84-07/87
- Invited Participant, NIH Workshop on PCR 06/30/88
- Invited participant NMMS meetings on MS, HTLV-1 and PCR, June 1989, Montreal, Canada
- Invited participant NCI symposia on HTLV-I, 1989.
- Invited participant NIAID symposia on detecting HIV-1 in urogenital fluids, October, 1991.
- Visiting Professor, Cleveland Clinic, February 18, 1992
- Honorary member, Association of Medical & Laboratory Immunologists, 1992-1993
- Invited Participant, NICHD/NIDCD Symposia on Infectious agents and SIDS
- Heritage Foundation Lecturer, Cross Cancer Institute Edmonton CANADA, 1994
- Cited in Marquis's Who's Who in the East, 1995
- Cited in Marquis's Who's Who in Science and Engineering, 1995
- Invited speaker NIDCD Council Meeting, May 18, 1995
- Alumni Citation Award, Alfred University, Alfred, New York, June 3, 1995
- Feinstein Lecturer, Alfred University, Alfred, New York, October 21, 1995
- Invited Guest, Visible Genetics, Toronto Ontario, Canada, June 26, 1996
- Invited Guest, Third Wave Technologies, Madison, Wisconsin, July 25-26, 1996.
- Invited Speaker, Association for Research in Otolaryngology's Workshop in Molecular Genetics, St. Petersburg Beach, Florida, February 1-6, 1997.
- Invited Speaker and Guest, Kaiyuan Bioengineering, Ltd., Xian, China, March 25-April 2, 1997.
- Invited Participant, NIDCD Workshop on Molecular Genetics of Language and Speech Acquisition, April 28, 1997.
- Career featured as cover story in the Sunday Magazine Section of the Pittsburgh Post Gazette, February 22, 1998.
- Keynote speaker, National Convention of Directors of Clinical Diagnosis Centers and the National Symposium of the Academic Exchange for young scientists, sponsoring agency, Health Ministry of P.R. China, Xian, China May 28, 1998.
- Work on medical biofilms featured in news article in Science, January 1999
- Honorary Professorship in Medical Genetics conferred by West China University of the Medical Sciences July 15, 1999, Award Ceremony October 11, 1999.
- Included in Marquis' Who's Who in America 2000, 2001, 2002.
- Invited Participant, DARPA biowarfare PI's conference, Ft. Lauderdale, FL, Jan 30-Feb 4, 2000.
- Guest of Honor, PAGER's Annual Walk-Run, San Diego, CA, September 21, 2000.
- National Institute of Deafness and Other Communication Disorders, Board of Scientific Counselors, October 2000.
- Invited Participant, NIH NIDCD Workshop, Otitis Media: New Approaches for Analysis, Treatment, and Prevention, Rockville, MD November 29-30, 2000.
- Invited Participant, MCP Hahnemann University Pre-Commencement Dinner with Dr. Craig Venter, Philadelphia, PA May 17, 2001
- Keynote Speaker, Indian Association of Medical Microbiology, Silver Jubilee Meeting, November 24, 2001 New Delhi, India
Memberships
| 1983-Date |
|
American Association for the Advancement of Science |
| 1990-Date |
|
American Society for Microbiology |
| 1990-1997 |
|
Pittsburgh Cancer Institute |
| 1991-2000 |
|
Academy of Clinical Laboratory Physicians and Scientists |
| 1992-1996 |
|
Association of Medical Laboratory Immunologists |
| 1993-Date |
|
Association for Research in Otolaryngology |
| 1993-1996 |
|
Society for Leukocyte Biology |
| 1994-Date |
|
Sigma Xi |
| 1994-Date |
|
Association for Molecular Pathology-Founding Member Infectious Diseases Committee Co-Chair 1994-1995 |
| 1996-Date |
|
American Society for Human Genetics |
| 1997-Date |
|
Pittsburgh Tissue Engineering Institute (mentor Award 1998, 1999, 2000, 2001) |
| 2000-Date |
|
American Academy of Otolaryngology-Head and Neck Surgery |
| 2001-Date |
|
Tissue Engineering Society |
Grant Support
Past |
| 08/88-07/89 |
|
Endowment for the Neurosciences-$12,052.00 (Principal Investigator) |
| 08/89-07/91 |
|
National Multiple Sclerosis Society- PCR-Based analyses for HTLV-I in MS $20,000 (Principal Investigator) |
| 1988-1991 |
|
National Heart, Lung and Blood Institute-Development and evaluation of new screening tests for human retroviruses. R01 HL-43602-01, $299,119 direct costs first year. (5% Effort) (Co-Investigator) (Bernard J. Poiesz, Principal Investigator) |
| 01/91-12/91 |
|
Pathology Education and Research Foundation-postdoctoral salary-$18,000 (Principal Investigator) |
| 07/91-06/92 |
|
Joint Development Fund-Sequence capture of PCR amplimers using a multiplex cyanine dye detection methodology. $20,000 Technician salary support. (Principal Investigator) |
| 09/89-08/92 |
|
National Heart Lung and Blood Institute-Development and evaluation of new screening tests for HTLV-III antigens, antibodies, or nucleic acids. N01-HB-67021, $320,790 direct costs first year (Co-Investigator) (5% Effort) (Bernard J. Poiesz, Principal Investigator) |
| 06/91-05/92 |
|
Otitis Media Research Center, $4,000.00 equipment grant (Co-Principal Investigator) |
| 09/91-10/92 |
|
Children's Hospital of Pittsburgh-New Research Project Fund. PCR-based detection of unculturable microorganisms in otitis media. $4,400.00. (Co-Principal Investigator) |
| 01/92-12/92 |
|
Blood Science Foundation-Development of HCV Diagnostic Assays. $25,000.00. (Principal Investigator) |
| 01/92-12/92 |
|
General Clinical Research Center, University of Pittsburgh, $4,000 for study of infectious organisms by rDNA PCR (Co-Principal Investigator) |
| 08/91-07/93 |
|
Stanley Foundation Research Awards Program-TCR_ usage in T lymphocytes isolated from the CSF of Schizophrenic patients. (Cathy McAllister, Principal Investigator, Garth Ehrlich, Co-Investigator) $12,800 direct costs for PCR subproject. |
| 04/92-03/93 |
|
Department of Pathology, Chairman's Discretionary Fund-Development of an automatable single stranded sequence capture technique using magnetic bead separation. $26,913.00 (Principle Investigator) |
| 07/92-06/93 |
|
The American Academy of Otolaryngology, Head and Neck Surgery Foundation -Academy Research Training Award, "PCR identification of M. catarrhalis DNA in chronic OME". $15,000 (Christopher Post-Principal Investigator) (Preceptor) |
| 07/92-06/93 |
|
The Pennsylvania Lions Hearing Research Foundation-Bacterial Detection in Middle-Ear Effusions Using the Polymerase Chain Reaction, $20,000 (Christopher Post-Principal Investigator, Garth Ehrlich-Co-Principal Investigators) |
| 07/92-06/94 |
|
Kodak Corporation, Comparative Analyses of PCR-Based Clinical Diagnostic Assays, $61,489 (Principal Investigator) |
| 07/92-06/94 |
|
Kodak Corporation, PCR Detection of Gram Negative Bacteremia and Antiviral Susceptibility testing of HIV-1, $292,904 (Principal Investigator) |
| 01/93-12/94 |
|
The Deafness Research Foundation-Development of a multiplex PCR-based assay to detect respiratory viruses associated with otitis media, $30,000 (Christopher Post, Garth Ehrlich -Co-Principal Investigators) |
| 06/93-05/94 |
|
Pathology Education and Research Foundation-Analysis of the chinchilla laniger animal mold of OME for PCR-based detection of H. influenzae. (Principal Investigator) |
| 07/94-06/95 |
|
Triological Society, The molecular biology of tissue injury and wound healing in sub glottic stenosis, $25,000 (Robert Yellow, Principal Investigator) (Co-Investigator). |
| 07/94-06/95 |
|
Triological Society, The molecular characterization of mutations and co-infections in juvenile laryngeal papillomas, $25,000 (Dr. Frank Rimell, Principal Investigator) (Preceptor). |
| 07/90-09/95 |
|
National Institute of Health, NIAID, Multicenter AIDS Cohort Study (20% Effort) (Charles Rinaldo, Jr., Ph.D., Principal Investigator, Garth Ehrlich, Co-Investigator) Viroimmunology subproject $70,000/annum in direct costs. |
| 01/91-04/96 |
|
Pittsburgh Supercomputing Center, Grant #DMB910001P Clinical Molecular Diagnostics -14.0 service units (Principal Investigator) |
| 07/95-06/96 |
|
Children's Hospital of Pittsburgh, Investigation of Mycoplasma pneumoniae as an Etiology of Recurrent Throat Infection in Children. $9800.00 (Robert Wadowsky, PI) (Co-Principal Investigator). |
| 07/94-12/95 |
|
General Clinical Research Center, Children's Hospital of Pittsburgh, PCR analysis of pediatric blood specimens for evidence of S. pneumoniae bacteremia. $19,330.86 (Principal Investigator) |
| 06/90-06/96 |
|
Pathology Education and Research Foundation-$160,000.00 (Principal Investigator) |
| 12/93-11/94 |
|
General Clinical Research Center, Children's Hospital-RT-PCR analysis of nasal secretions for individuals challenged with influenzae virus infection, $5,500 (Principal Investigator). |
| 05/01/95-04/30/97 |
|
NIH RO3, Microsatellite Mapping of Saethre-Chotzen Syndrome, 50,000 (Robert Preston, Principal Investigator) (Co-Investigator and Preceptor). |
| 07/01/95-06/30/98 |
|
NIH, NIAID, Characterization of HIV in sexual transmission. (Phalguni Gupta, Principal Investigator) (Co-Investigator). |
| 9/96-8/98 |
|
NIH, NIDDK, PAR-95-078 "Genetic linkage in patients with Hereditary Pancreatitis" (Co-Principal Investigator) Direct costs for first year-$50,000. |
| 9/96-8/98 |
|
Eli Lily, Loribid Trial-PCR for URVI. $15,000. |
| 02/97-1/98 |
|
National Kidney Foundation, "Clinical, Biochemical and Molecular Genetic Characterization of Persons and Families with Vesicoureteral Reflux". (Mentor) Total Project Funding: $25,000.00 |
| 01/97-12/98 |
|
Crohn's and Colitis Foundation of America "Genetic linkage of inflammatory bowel disease"; (Co-Principal Investigator) Direct Costs for first year-$80,000. |
| 09/94-08/99 |
|
NIH, NIAID, AIDS Training Grant (5% Effort) (Charles Rinaldo, Jr., Ph.D., Principal Investigator, Garth Ehrlich, Co-Investigator) Total Project Funding: $1,166,178. |
| 07/94-06/2000 |
|
NIH, NIDCD, R29DC02398-01, Genetic mapping of a syndrome with hearing impairment, $70,000 direct costs per year (Dr. J. Christopher Post, Principal Investigator) (Preceptor and Consultant) |
| 9/96-9/99 |
|
NIH DC-95-13 "Molecular Analyses of Autopsy Specimens from SIDS and Control Infants to Ascertain Middle-Ear Infection" (Principal Investigator) Direct costs for first year-$75,111. |
| 07/95-06/00 |
|
NIH NIDDK DK-94-022, Alcohol and altered regulation of pancreatic secretion, $149,909 direct costs year one (David C. Whitcomb, PI) (Co-Principal Investigator). |
Current |
| 12/93-03/03 |
|
NIH NIDCD, 2R01DC02148, Molecular Analysis of Pathogens in Otitis Media by PCR, $362,496 costs year eight (Principal Investigator). |
| 07/00-6/2003 |
|
NIH-NIDCD, R01DC04173- The Role of Biofilms in the Pathogenesis of Otorrhea, $742,262 direct costs first year. Three year total: $3,091,316 (Principal Investigator). |
| 07/2000- 06/2004 |
|
NIH-NIDCD-RO1-DC04591-01 The Genetics of Gastroesophageal Reflux, $225,000 direct costs/year (Principal Investigator). |
| 07/2000-06/2005 |
|
NIH-NIDCD- 2 R01 DC02398-08A1 Molecular Genetics of a Syndrome with Hearing Impairment, $250,000 direct costs first year, (Co-Investigator; Dr. J. Christopher Post, PI). |
| 01/2000-Date |
|
Pfizer-Molecular Diagnostics for Clinical Trials (protocols 1015, 1016, 1039 and 1043) $150,000 (Principal Investigator) |
| 04/2002- Date |
|
Motorola-Comparative Gene Expression of Calvarial Sutures in a Chimeric Human Ostoeblast/ Nude Rat Model. $7000 [in reagents] (Principal Investigator) |
| 05/2002-Date |
|
Biogen-Comparative Gene Expression of Cytokines in Treated and Untreated Patients with Relapsing-Remitting Multiple Sclerosis. $60,617 (Principal Investigator) |
| 06/2002-05/2003 |
|
The Buhl Foundation "Henry C. Frick Educational Fund of the Buhl Foundation" Professional Development Program in Molecular Genetics and Biotechnology for High School Biology Teachers $19,680 (Sponsor; Dr. Eva Erdosne Toth, PI). |
| 10/2002-09/2005 |
|
Allegheny Orthopedic Associates. Molecular Analyses of Bacterial Biofilms associated with Osteomyletis following Total Joint Replacement. $133,000 first year ($400,000 direct costs total) (Principal Investigator) |
| 08/2002-07/2005 |
|
National Science Foundation (NSF) $356,000 total costs (Co-investigator; Dr. Eva Erdosne Toth, PI) |
| -Pending- |
|
NIH/NIDCD R01 DC05659-01 Pneumococcal Biofilms in Otitis Media 07/01/02-6/30/07 $475,000 (1st year direct costs) (Co-Principal Investigator; Dr. J. Christopher Post, PI). |
| -Pending- |
|
NIH/NIDCD R01 DC05631-01 Bacterial Genomic Plasticity a Mechanism of Hearing Loss (07/01/02-6/30/07) $250,000 (1st year direct costs) (Co Investigator; Dr. Geza Erdos PI). |
| -Pending- |
|
NIH/HIDCD K08 Genetics of Papilloma-induced Voice Disturbance (12/01/02-11/30/07) $179,500 (1st year direct costs) (Mentor; Dr. Buchinsky PI). |
| -Pending- |
|
NIH/NIDDK R01-Response to RFA on Genetics of Barrett's Esophagus (03/20/02-submission date) (PI WPAHS subcontract; Hashem El Serag PI, Baylor COM) |
| -Pending- |
|
NIH.NIDCD 3R01DC02148, Molecular Analysis of Pathogens in Otitis Media by PCR (03/01/02-2nd renewal early submission date for year 10-14) |
Students/Mentorships
Graduate Students
Lauren Bruckner-M.D./Ph.D. Student at SUNY HSC at Syracuse; Topic-The role of HTLV-I proviral integration, or lack thereof, on retroviral expression and pathogenicity. (Co-Mentor 1989-90)
Michael Sherman-M.D./Ph.D. Student at SUNY HSC at Syracuse; Topic-Examination of HTLV-I proviral flanking sequences in chromosomal DNA by means of ligation mediated PCR. (Co-Mentor 1989-90)
Timothy Oriss-Ph.D. Candidate, Department of Infectious Diseases and Microbiology, University of Pittsburgh (Committee Member)-Ph.D. awarded June 1993.
Debbie Boldt-Ph.D., Admitted to candidacy 1992, Ph.D. awarded September 1994, Department of Pathology, University of Pittsburgh (Mentor). Currently in Biotechnology Industry.
Alexa Sirko-Ph.D., Admitted to candidacy 1993, Ph.D. awarded with honors, November 1995, Department of Pathology, University of Pittsburgh (Mentor). Currently Assistant Professor of Human Genetics, Case Western Reserve University
James Christopher Post, M.D., Professor of Otolaryngology-Ph.D. Admitted to candidacy 1995, Ph.D. awarded May 1999, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh (Mentor, ex officio). Currently Director Pediatric ENT, Allegheny General Hospital and Medical Director Center for Genomic Sciences, Allegheny Singer Research Institute
Jasmin Dada-M.S. Student, Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh (Thesis Committee)-M.S. awarded 1992
Stella Laus-M.S. Student, Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh (Thesis Committee)-M.S. awarded December, 1993
Yingze Zhang-Ph.D. Student, Passed qualifying exams, June 1995, Ph.D. Ph.D. awarded with honors December 1997. Department of Pathology, University of Pittsburgh (Mentor). Currently, Assistant Professor University of Pittsburgh School of Dentistry
Kirsten St. George-Ph.D. Student, Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh (Doctoral Exam and Dissertation Committees)
Chaofo Shi-Ph.D. Student, Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh (Ph.D. Oral Comprehensive Examination Committee)
Meisheng Chen-Ph.D. Student, Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh (Ph.D. Oral Comprehensive Examination Committee)
Maria Victoria Dolor-M.S. Student, Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh (Thesis Committee)-M.S. Awarded March 1996.
Anita Beyer-M.S. Student, Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh (Thesis Committee)-M.S. awarded December, 1995
Li Zheng-Ph.D. Student, Department of Pathology, Univeresity of Pittsburgh, School of Medicine-Summer 1996.
Erin Beth Summerly-M.S. Thseis Committee Member, Department of Infectious Disease and Microbiology, Graduate School of Public Health-M.S. Awarded July, 1997.
Devin Dressman-Ph.D. student, Biomedical Graduate Program, University of Pittsburgh Summer 1997 (transferred to Eric Hoffman's Lab when I left). Ph.D awarded 2001.
Fen Ze Hu-Ph.D. Student, Graduate Program in Molecular and Human Genetics, Center for Genomic Sciences, Allegheny University of the Health Sciences. M.S. awarded with Distinction, May 1999 (due to breakup of AUHS), Currently, Laboratory Manager Center For Genomic Sciences, ASRI. Ph.D. Candidate MCP-Hahnemann School of Medicine.
Jeffrey Dingman-Ph.D. Student, Graduate Program in Molecular and Human Genetics, Center for Genomic Sciences, Allegheny University of the Health Sciences. M.S. awarded, May 1999 (due to breakup of AUHS). Currenetly, medical student University of Pittsburgh.
Michael Gorry-Ph.D. Student, Graduate Program in Molecular and Human Genetics, Center for Genomic Sciences, Allegheny University of the Health Sciences. (left program because of AUHS bankruptcy 10/98)
Xiaobin Dai-Ph.D. Student, Graduate Program in Molecular and Human Genetics, Center for Genomic Sciences, Allegheny University of the Health Sciences. (died 4/98)
Post-doctoral Fellows
Basavaraju Shankarappa, Ph.D. (Ph.D. University of Maryland) Correlation of env gene Genotype and clinical Phenotype of HIV-1 isolates from members of the MACS cohort. (1991-1994). Currently on faculty at University of Washington in Seattle.
Hawazin Faruki, Ph.D. Development of Molecular Diagnostics for Viral Pathogens associated with solid organ transplant. (1992-1994). Previously Director of Molecular Diagnostics for The Central Blood Bank, Pittsburgh PA. Current position unknown.
Sameera Sayeed, Ph.D. (Ph.D. Bangladesh; National Institutes of Health post doc) Construction, characterization and normalization of gene expression libraries for creation of RNA arrays to study the gene expression patterns of host and pathogen associated with mucosal biofilm diseases. (2000-present)
Patricia Antalis, Ph.D. (Ph.D. Ohio State University; Carnegie Science Center post doc). Construction, characterization and normalization of gene expression libraries for creation of RNA arrays to study the gene expression patterns of normal and abnormal bony development of the calvaria. (2000-present)
Azad Ahmed, M.D. (M.D. Bangladesh) Positional cloning of the GER gene; Gene mapping of GER and Dupuytren's contracture. (2001-present)
Joseph Goodwin, D.P.M. Genomic plasticity of bacterial pathogens (2001-present)
Kai Shen, M.D., M.S. (M.D., M.S. West China University of the Medical Sciences, Chengdu, Sichuan, China) Genomic plasticity of bacterial pathogens (2001-present)
Faculty Mentored and/or Supervised
Robert Wadowsky, Sc.D. (Currently, Associate Professor of Pathology, University of Pittsburgh & Director of Clinical Microbiology, Children's Hospital of Pittsburgh) Provided training in molecular diagnostics for infectious agents. (1991-1997)
Parmjeet Randawa, M.D. (Currently, Associate Professor of Pathology, University of Pittsburgh School of Medicine) Provided training in molecular diagnostics for infectious agents (1991-1994)
Robert Preston, Ph.D (Currently Research Associate Professor of Biochemistry{appointment pending}, Drexel University College of Medicine) Provided training and oversight in Genetic Mapping, Linkage Analysis, and Sequence Analysis. (1992-Date)
Xue Wang M.D., M.S. (Currently Research Assistant Professor of Microbiology and Immunology, Drexel University College of Medicine) Provided training in animal models of microbiological research and protein biochemistry.
Geza Erdos, Ph.D. (Currently Research Assistant Professor of Microbiology, Drexel University College of Medicine). Provided mentoring in NIH grant writing, personnel management, and career positioning. Provided training in production and screening of arrayed libraries and micro-aarrays (2000-Date)
Basavaraju Shankarappa, Ph.D., D.V.M (Currently Assistant Professor of Microbiology and Immunology, MCP-Hahnemann University School of Medicine). Provided mentoring in NIH grant writing, personnel management, and career positioning
Sandeep Kathju, M.D., Ph.D. (Currently Assistant Professor of Surgery, MCP-Hahnemann University School of Medicine). Provided mentoring in project selection, and NIH grant submissions. Serve as sponsor on K08 career development award submitted 2001.
Farrell Buchinsky, M.D. (Currently Assistant Professor of Surgery, {appointment pending} MCP-Hahnemann University School of Medicine). Provided mentoring in project selection, and NIH & foundation grant submissions. Serve as sponsor on K08 career development award (01/01/2003-12/31/2007)
Medical Student Research Fellowships
Keri Lavigne-Medical Student Research Program-SUNY HSC at Syracuse; Topic-differentiation of HTLV-I and II by immunoblot, PCR and RT-PCR of plasma/serum. M.D. 1990 (Primary Advisor)
Mark Malone-Post-sophomore Fellow, Department of Pathology, University of Pittsburgh (90-91)
Tylis Chang-Post-sophomore Fellow, Department of Pathology, University of Pittsburgh (91-92)
Margaret Pettigrew-Post-sophomore Fellow, Department of Pathology and Otolaryngology, University of Pittsburgh (91-92)
Jill Rydquist-White-Post-sophomore Fellow, Department of Pathology, University of Pittsburgh (92-93)
Tylis Chang-Post-sophomore Fellow, Department of Pathology, University of Pittsburgh (92-93) (Co-sponsor)
Kenneth Anderson-Post-sophomore Fellow, Department of Pathology, University of Pittsburgh (93-94) First Place Award in the Medical Student/Post-sophomore Fellow category of the Fifth Annual Research Presentation Day Competition.
Jerry Aul-Medical Student Summer Research Program-Medical Alumni Association, University of Pittsburgh, Summer, 1993 and Post-sophomore Fellow (1994-1995), Department of Pathology, University of Pittsburgh (1994-95)
Derek Armfield-Medical Student Summer Research Program-Medical Alumni Association, University of Pittsburgh, Summer, 1994-Received Travel Award from ARO to present his poster at the National Meeting.
Daryle Darden-Post-sophomore Fellow, Department of Pathology, University of Pittsburgh (96-97).
Mark Rayner-Medical Student Research Fellowship, University of Pittsburgh (96-97).
Erin O'Brien-Medical Student Research Program-Medical Alumni Association-University of Pittsburgh (97).
Christopher Polling-Medical Student Research Program-Medical Alumni Association-University of
Pittsburgh (97).
Cindy Nelson-Medical Student Research Program-Medical Alumni Association-University of Pittsburgh (97).
Demetri Laddis -Medical Student Research Program-Medical Alumni Association-University of Pittsburgh (97).
Jay Stutz-Medical Student Research Program-Medical Alumni Association-University of Pittsburgh (97).
Sy Catinuo-Medical Student Research Program-Medical Alumni Association-University of Pittsburgh (97).
Dorothea Yee-Medical Student Research Rotation-MCP-Hahnemann University-October 1999
Gregory White-Medical Student Summer Intern-Osteopathic School of Philadelphia-Summer 2000
Mina Cherapoo-Medical Student Research Rotation-MCP- Hahnemann University-April-July 2001
Resident and Fellow Laboratory Internships
Anthony Magit, M.D. -Pediatric Otolaryngology Fellow, Children's Hospital of Pittsburgh (1990-1992)
J. Christopher Post, M.D.-Pediatric Otolaryngology Fellow, Children's Hospital of Pittsburgh (1990-1992)
Frank Rimmel, M.D.-Pediatric Otolaryngology Fellow, Children's Hospital of Pittsburgh (1994)
Andrew Shapiro, M.D.-Pediatric Otolaryngology Fellow, Children's Hospital of Pittsburgh (1994)
David Shoemaker, M.D.-Otolaryngology Resident, Department of Otolaryngology, University of Pittsburgh (1994)
Sean Houston, M.D.-Otolaryngology Resident, Department of Otolaryngology, University of Pittsburgh (1994)
Eric Leiderman, M.D.-Otolaryngology Resident, Department of Otolaryngology, University of Pittsburgh (1994)
Ana Pou, M.D.-Otolaryngology Resident, Department of Otolaryngology, University of Pittsburgh (1994, 1995)
Wasyl Szerameta, M.D.-Pediatric Otolaryngology Fellow, Children's Hospital of Pittsburgh (1995-1996).
Suman Mishra, M.D.-Pediatric Otolaryngology Fellow, Resident, Children's Hospital of Pittsburgh (1997).
Daniel Herz, M.D.-Urology Resident, Department of Urology, University of Pittsburgh, (1996-1997).
Steven Krakora, D.M.D-Oralomaaxillofacial Surgery Resident, Department of Oralomaxillofacial surgery, Allegheny General Hospital (1999-2000)
Sandeep Kathju, Ph.D., M.D.-Plastic Surgery Fellow, Departments of Plastic Surgery University of Pittsburgh and Allegheny General Hospital, (2000-2001)
Lise Roberts, M.D.-Obstetrics/Gynecology Fellow, Department of OB/GYN, Allegheny General Hospital (2000-2001)
Undergraduate Internships
Adil Waheed-Penn State University, Summer 1991-Matriculated at medical school
Soma Gupta-University of Michigan, Summer 1991, 1993-Matriculated at Pharm D. school
Thomas Zavoral-Grove City College, Summer 1992, 1994-Matriculated at University of Pittsburgh Medical School
Sandra Mitre-Dartmouth College, Summer 1993-Matriculated at medical school
Jennifer Barnes-Chatham College, Summer 1993
Pierre Barua-Bucknell University, Summer 1994, Summer 1995, Summer 1996
Mark Cardamone-Raynor-University of Pittsburgh, Summer 1995-Matriculated at University of Pittsburgh Medical School. Summer, 1996. ENT Resident University of Minnesota
Ari Goldberg-University of Pittsburgh, Summer 1995-Spring 1997-Matriculated University of Pennsylvania School of Medicine.
Bobby Aichbhaumik-Wayne State University, Summer 1995, Summer 1996-Matriculated at Wayne State University Medical School 1997.
Lexi Wong-Cheng-McGill University, Summer 1995
Devin Dressman-Alfred University, Summer 1996-Matriculated U of Pittsburgh Biomedical Ph.D. Program 1997
Michael Bummer-Cornell University, Summer 1998
William Chong-Penn State University, Summer 1998, Summer 2001-Matriculated at Temple University School of Medicine 2001
Samir Mehta-Duke University, Summer 1998
Scott Barcus-Grove City College, Summer 1998
Bernie Daigle-Cornell University, Summer 1999, Summer 2000, Summer 2002
Michael Sweeny-Ohio University, PTEI Fellowship Summer 1999, Summer 2000
Christine Chong-Penn State University, Summer 1999, Summer 2000, Summer 2001
Nathan Ehrlich-Taylor Allderdice High School, Summer 1999
Cara Rebeck-Wellesley College, Summer 2000
Sandy McMann-Edinboro University of PA., Summer 2000
Angela Harter-Penn State University, Summer 2001
Megan -Penn State University, Summer 2001
Terra Rupert-Allegheny College, Summer 2001
Adam Abdulally-University of Pittsburgh, Summer 2002
Minority Student Internships
Margaret Larkins-Pettigrew-medical student post-sophomore fellowship 1991-1992, Department of Otolaryngology and Pathology-Awarded 1st place for research at the National Medical Student Association Annual Meeting (1992).
Monique Brown-Westinghouse High School, Heritage Minority Student Internships, NIH Sponsored, Summer 1994.
International Guests
Stefan Emler, M.D.-Laboratoire Central de Bacteriolgie, Hopitaux Universitaires de Geneve (November 1995, April 1997).
Joseph Gluestein-Israel (1996-1998)
Dai Xiaobin-Sichuan Institute of Parasitic Disease-Sichuan, P.R. China-1997-1998.
Qinhua Liu-Sichuan Institute of Parasitic Disease-Sichuan, P.R. China-1997-1998.
Susanta Roychodhury-Calcutta-awaiting visa.
Teaching
MCP-Hahnemann University School of Medicine
Graduate Program -Developed Ph.D./M.S. graduate programs in Molecular and Human Genetics at the Allegheny Campus of Allegheny University of the Health Sciences which consisted of a 10 hour 2 semester core course in Biochemistry, Molecular Genetics, Human Genetics, Cell Biology and Physiology.
First Semester |
| Nucleic acid composition |
|
Nucleic acid 1° structure |
| Nucleic acid evolution |
|
Nucleic acid measurements |
| Nucleic acid 2° & 3° structures |
|
Primitive earth environments and |
| Introduction to the Archea |
|
evolution of life |
| The Burckner-Marshall Hypothesis |
|
Prokarya Genomics-Gene structure |
| Prokarya Genomics-Phage genetics |
|
Methods of flux across membranes |
| The synapse and signal propagation |
|
Saccharide biochemistry and cellular |
| Photosynthesis and the Calvin cycle |
|
energy transduction schemes |
| The electron transport chain |
|
Metabolic rates |
| DNA replication history and theory |
|
Replication of episomal elements |
| RNA replication |
|
RNA modification and structure determinants |
| RNA synthesis in vitro |
|
Operons and prokaryotic mRNA transcription |
| Effects of environmental change on gene expression |
|
Bacterial responses to stimuli |
| Eukaryotic transcription-three systems |
|
|
Second Semester |
| The adaptor hypothesis-Crick |
|
Bacterial responses to stimuli |
| Lysogenic plage and stimuli |
|
Protein structure analysis |
| Protein classes and properties |
|
Regulation of enzymes |
| Enzyme inhibition systems |
|
Co-enzymes and metal ions |
| Protein synthesis and sequence |
|
Protein structure determination |
| Prions and prion diseases |
|
Intro to Mutations and Evolution |
| Designed Mechanisms of Mutation/Bacterial Adaption Theories |
|
Darwinian and NeoDarwinian Evolution |
| Bacterial DNA transfer processes |
|
Eukaryotic Transposable Elements II |
| Cancer Genetics-Oncogenes |
|
Tumor Suppresor Genes |
| Exon Trapping |
|
|
Resident Teaching (1998)-Organized didactic curriculum for pathology residents molecular diagnostics rotation-delivered 6 one hour lectures.
University of Pittsburgh
Graduate Students
University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology; Course #2010-Lectured and assisted with testing on human retroviral diagnostics and pathogenesis. (1991)
University of Pittsburgh, School of Medicine, Department of Pathology; Immunogenetics-Lectured and assisted with testing on molecular based approaches to studying immune system super gene families. (1992, 1993)
University of Pittsburgh, School of Medicine, Department of Pathology; Makeup and Administration of Ph.D. qualifying exams (1992, 1993, 1994, 1995).
University of Pittsburgh, School of Medicine, Department of Pathology; Cancer Biology Course-2 lectures: 1) DNA Tumor Viruses; 2) RNA Tumor Viruses (Spring 1993; Spring 1994; Spring 1995; Spring 1996); and examiner for student presentations (1995, 1996).
University of Pittsburgh, School of Medicine, Department of Pathology; General Human Pathology Course-2 lectures on Retroviral Pathogenesis and Molecular Diagnostics for Infectious Disease (Spring 1995; Spring, 1996).
University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, Methods in Infectious Disease Epidemiology Course, Lecture on use of Molecular Diagnostics to Develop new insights into chronic infectious processes (Spring 1999; Spring 2000)
Medical Students
University of Pittsburgh, School of Medicine, Department of Pathology; PMS II Pathology Course-(1991-1992). Sponsored three student presentations: demyelinating diseases; prion protein diseases; human retroviral neoplasias.
University of Pittsburgh, School of Medicine, Department of Pathology; PMS II Pathology Course-(1992-1993). Sponsored four student presentations: demyelinating diseases; prion protein diseases; human retroviral neoplasias; development of methods to identify new microbial pathogens.
University of Pittsburgh, School of Medicine, Department of Pathology; Sophomore Pathology Course -lectured on "Diagnosis of Infectious Agents by Molecular Techniques" (Fall 1992).
University of Pittsburgh, School of Medicine, Clinical Epidemiology, Small Group Recitation.
Pathology Residents
University of Pittsburgh, School of Medicine, Department of Pathology, Resident training program lecture in Molecular Diagnostics, September, 1992.
University of Pittsburgh, School of Medicine, Department of Pathology, Resident training program lecture in Molecular Diagnostics, January 1993. Coordinate Pathology residents lab rotations through PCR Core Facility.
Coordinated molecular microbiology and nucleic acid amplification strategies sections of the second year Pathology residents course in Molecular Diagnostics. Delivered seven 60-90 minute lectures and helped with preparation of final examination (1993, 1994, 1995).
Coordinated PCR-based detections strategies and molecular microbiology for the Molecular Diagnostics course taught in the School of Health and Rehabilitation Sciences (7 lectures). Delivered 2-75 minute lectures and prepared sections of midterm and final exam.
Committees
Allegheny University of the Health Sciences/MCP-Hahnemann School of Medicine/Allegheny General Hosptial
Institutional Animal Care and Use Committee (1998-Date; Vice Chairman- 2000-Date)
Allegheny General Hospital Chair's Executive Committee (2000-Date)
Allegheny Singer Research Institite, Research Committee (2000-Date)
MCP-Hahnemann School of Medicine-School of Medicine Research Committee (2001-Date)
Pittsburgh Tissue Engineering Initiative, Inc
Summer Intern Selection Committee (2000, 2001)
University of Pittsburgh (University-wide)
Institutional Biosafety Committee (1992-1995; extended to 1997)
University of Pittsburgh, Department of Pathology
Graduate Education Committee (1990)
Curriculum Subcommittee (1990)
Speaker Selection Committee (1991)
Cellular and Molecular Pathology Coordinating Committee (1991-Date)
Graduate Admissions and Education Committee (1991-1994)
Faculty Search Committee-Molecular Biology Position, Magee Hospital
Post Sophomore Fellowship Selection Committee (1992-1993)
Graduate Evaluations Committee (1992-1997)
Research Associate Search Committee (1994)
Research Associate Search Committee Chairman (1995)
Research Associate Search Committee Chairman (1996)
University of Pittsburgh, Department of Infectious Diseases and Microbiology
Research Associate Search Committee-Cellular Immunologist Position (1991)
Publications
-Editorials, βInvited Reviews & γCitations |
| E-1β |
|
Ehrlich, G.D.: Caveats of PCR. Clinical Microbiology Newsletter 13:149-151, 1991. |
| E-2β |
|
Ehrlich, G.D.: Molecular Methods for Clinical Immunologists: Innovations and Interpretations. AMLI Newsletter 4:6, 1992. |
| E-3- |
|
Ehrlich, G.D.: Editorial requested by Journal of Craniofacial Surgery. (Under development) |
| E-4- |
|
Ehrlich, G.D.: Syndromic Illnesses Demand Multiplex PCR-Based Assays. Molecular Diagnosis 1: 83-87, 1996. |
| E-5- |
|
Ehrlich, G.D.: Otitis Media-Prospects for Management. International Clinical Practice Series, p7, 1996. |
| E-6- |
|
Ehrlich, G.D.: What do new diagnostics tell us about the effectiveness of treatment of otitis media? International Clinical Practice Series, pp 9-13, 1996. |
| E-7β |
|
Ryan, A.F, Diven, W.F., Bakaletz, L.O., Ehrlich, G.D., Juhn, S.K., Jung, T.T.K., and Post, J.C. 5A Biochemistry. Recent Advances in Otitis Media: Report of the Sixth Research Conference. Annals of Otology, Rhinology and Laryngology. 107 (S174), 50-55, 1998. |
| E-8β |
|
Ryan, A.F, Diven, W.F., Bakaletz, L.O., Ehrlich, G.D., Juhn, S.K., Jung, T.T.K., and Post, J.C. 5B Molecuklar Biology. Recent Advances in Otitis Media: Report of the SIxth Research Conference. Annals of Otology, Rhinology and Laryngology. 107 (S174), 50-55, 1998. |
| E-9γ |
|
Potera, C. Forging a Link Between Biofilms and Disease. Science 283:1837-1839, 1999. |
| E-10- |
|
Ehrlich, G.D.* and Post, J.C. Susceptability to Otitis Media: Strong Evidence that Genetics Plays a Role. JAMA 282:2167-2169, 1999 |
| E-11β |
|
Post, J.C. and Ehrlich, G.D*. The Impact of the Polymerase Chain Reaction in Clinical Medicine. JAMA 283:1544-1546 2000 |
-Rapid Publication and -Special Articles |
| 1.+- |
|
Bhagavati, S., Ehrlich, G., Kula, R., Sninsky, J., Kwok, S., Udani, O., and Poiesz, B.J.: Detection of human T-cell lymphotropic virus-Type I in the spinal fluid and blood of cases of chronic progressive myelopathy and a clinical, radiological and electrophysicological profile of HTLV-I associated myelopathy. N. Engl. J. Med. 318:1141, 1988. |
| 2.+- |
|
Abbott, M., Byrne, B., Kwok, S., Sninsky, J., Poiesz, B., and Ehrlich, G.D.*: Enzymatic gene amplification: Qualitative and quantitative methods for detecting proviral DNA amplified in vitro. J. Inf. Dis. 158:1158-1169, 1988. |
| 3.- |
|
Ehrlich, G.D.*, Glaser, J., Abbott, M., Salmon, D.J., Keith, D., Sliwkowski, M., Brandis, J., Keitelman, E., Teramato, Y., Papsidero, L., Sninsky, J.J., and Poiesz, B.J.: Detection of Anti-HTLV-I tax antibodies in HTLV-I ELISA negative risk group members. Blood 74:1066-1072, 1989. |
| 4.o$- |
|
Ehrlich, G.D.*, Glaser, J.B., Maese, J., Bryz-Gornia V., Waldmann, T.A., Poiesz, B.J., Greenberg, S.J. and the HTLV-I MS working group. Multiple Sclerosis, Retroviruses and PCR. Neurol. 41:335-343, 1991. |
| 5.- |
|
Loughran, T.P., Coyle, T., Sherman, M.P., Starkebaum, G., Ehrlich, G.D., Ruscetti, F.W., Poiesz, B.J. Detection of human T-cell leukemia/lymphoma virus Type II in a patient with LGL Leukemia. Blood 80:1116-1119, 1992. |
| 6.- |
|
Boldt-Houle, D.M., Rinaldo, C.R., Jr., Ehrlich, G.D.*: Random depletion of T-cells that bear specific T-cell receptor V- sequences in AIDS patients. J. Leukoc. Biol. 54:486-491, 1993. |
| 7.-^ |
|
Preston, R.A., Post, J.C., Keats, B.J.B., Aston, C.E., Ferrell, R.E., Priest, J., Nouri, N., Losken, H.W., Morris, C.A., Hurtt, M.R., Mulvihill, J.J., and Ehrlich, G.D. A gene for Crouzon craniofacial dysostosis maps to the long arm of chromosome 10. Nature Genetics 7:149-153, 1994. |
| 8.- |
|
Gorry, M.C., Preston, R.A., White, G.J., Zhang, Y., Singhal, V.K., Losken, H.W., Nwokoro, N.A., Post, J.C., and Ehrlich, G.D. Crouzon Syndrome: Mutations in two spliceoforms of FGFR2 and a common point mutation shared with Jackson-Weiss Syndrome. Hum. Mol. Gen. 4:1387-1390, 1995. |
| 9.+ |
|
Whitcomb, D.C., Preston, R.A., Aston, C.E., Sossenheimer, M.J., Barua, P.S., Zhang, Y., Wong-Chong, A., White, G.J., Wood, P.G., Gates, L., Ulrich, C., Martin, S.P., Post, J.C., and Ehrlich, G.D. A Gene for Hereditary Pancreatitis Maps to an 19 cM Locus on Chromosome 7q35. Gastroenterology. 110:1975-1980, 1996. |
| 10.+ |
|
Gemel, Joanna., Gorry, Michael., Ehrlich, G.D., and MacArthur, Craig A. Structure and sequence of human FGF8 gene suggest that several protein isoforms are unimportant for vertebrate development. Genomics 35: 253-257, 1996. |
| 11. |
|
Whitcomb, D.C., Gorry, M.C., Preston, R.A., Furey, W.F., Sossenheimer, J.J., Ulrich, C.D., Martin, S.P., Gates, L.K. Jr., Amann, S.T., Toskes, P.P., Liddle, R., McGrath, K. Uomo, G., Post, J.C., and Ehrlich, G.D.* Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nature Genetics 14:145, 1996. |
| 12. |
|
Gorry, M.C., Gabbaizedeh, D., Furey, W., Gates, Jr., L.K., Preston, R.A., Aston, C.E., Zhang, Y., Ulrich, C., Ehrlich, G.D., and Whitcomb, D.C. Multiple mutations in the cationic trypsinogen gene are associated with hereditary pancreatitis. Gastroenterology 113:1063-1068, 1997. |
Peer-Reviewed Literature |
| 13. |
|
Merl, S., Kloster, B., Moore, J., Hubbell, C., Tomar, R., Davey, F., Kalinowski, D., Planas, A., Ehrlich, G.D., Clark, D., Comis, R., and Poiesz, B.: Efficient transformation of previously activated and dividing T-lymphocytes by human T-cell leukemia-lymphoma. Blood 64:967-974, 1984. |
| 14. |
|
Moore, J.L., Poiesz, B.J., Tomar, R.H., Merl, S.A., and Ehrlich, G.D.: Gamma interferon and AIDS. N. Engl. J. Med. 312:442-443, 1985 (letter). |
| 15. |
|
Graziano, S.L., Lehr, B.M., Merl, S.A., Ehrlich, G.D., Moore, J.L., Hallinan, E.J., Hubbell, C., Davey, F.R., Vournakis, J., and Poiesz, B.J.: Quantitative assay of human T-cell leukemia/lymphoma virus transformation. Cancer Research 47:2468-2473, 1987. |
| 16. |
|
Kwok, S., Mack., D.H., Mullis, K.B., Poiesz, B., Ehrlich, G., Blair, D., Friedman-Kien, A., and Sninsky J.J.: Identification of human immunodeficiency virus sequences by using in vitro enzymatic amplification and oligomer cleavage detection. J. Virology, 61:1690-1694, May 1987. |
| 17. |
|
Krichbaum-Stenger, K., Poiesz, B.J., Keller, P., Ehrlich, G., Gavalchin, J., Davis, B.H., and Moore, J.L.: Specific adsorption of HTLV-I to various target human and animal cells. Blood 70:1303-1311, 1987. |
| 18. |
|
Ehrlich, G.D., Han, T., Bettigole, R., Merl, S.A., Lehr, B., Tomar, R.H., and Poiesz, B.J.: HTLV-I associated benign transient immature T-cell lymphocytosis. Amer. J. Hemat. 27:49-55, 1988. |
| 19. |
|
Duggan, D.B., Ehrlich, G.D., Davey, F.P., Kwok, S., Sninsky, J., Goldberg, J., Kirshner, J., Baltrucki, L., and Poiesz, B.J.: HTLV-I induced lymphoma mimicking Hodgkin's disease and Wegener's granulomatosis. Diagnosis by polymerase chain reaction amplification of specific HTLV-I sequences in tumor DNA. Blood 71:1027-1032, 1988. |
| 20. |
|
Bustros, A., Nelkin, B.D., Silverman, A., Ehrlich, G., Poiesz, B.J., Baylin, S.B.: Regional DNA de-hypermethylation: Implications for human neoplasia. Proc. Natl. Acad. Sci. USA. 85:5693-5697, 1988. |
| 21. |
|
Graziano, S.L., Mark, G.E., Murray, C., Mann, D.L., Ehrlich, G.D., Poiesz, B.J., Weston, A.: DNA restriction fragment length polymorphism at either end of the c-raf-1 locus at 3p25. Oncogene Res. 3:999-103, 1988. |
| 22. |
|
Kwok, S., Ehrlich, G., Poiesz, B., Kalish, R., and Sninsky, J.J.: Enzymatic amplification of HTLV-I viral sequences in peripheral blood mononuclear cells and infected tissues. Blood 72:1117-1123, 1988. |
| 23. |
|
Kwok, S., Ehrlich, G., Poiesz, B., Bhagavati, S., and Sninsky, J.J.: Characterization of a HTLV-I sequence from a patient with chronic progressive myelopathy. J. Infect. Dis., 158:1193-1197, 1988. |
| 24. |
|
Rowley, A.H., Shulman, S.T., Preble, O.R., Poiesz, B.J., Ehrlich, G.D., Sullivan, J.R.: Serum interferon levels and retroviral serology in Kawasaki Syndrome. Ped. Inf. Dis. J 7:663-665, Sept., 1988. |
| 25. |
| Glaser, J.B., Coleman, P., Salmon, D., Papsidero, L., Ehrlich, G.D., Poiesz, B.J., Duggan, D.: Prevalence of HTLV-I and HIV infection among white parenteral drug abusers. Journal of Acquired Immunodeficiency syndrome, 1:415-417, 1988.
| 26. |
|
Ehrlich, G.D., Davey, F., Kwok, S., Sninsky, J., Kirshner, J., Kalish, R., Planas, A., and Poiesz, B.: A polyclonal CD4+ and CD8+ lymphocytosis in a patient doubly infected with HTLV-I and HIV-1. Am. J. Hematol., 30:128-139, 1989. |
| 27. |
|
Greenberg, S.J., Ehrlich, G.D., Abbott, M.A., Hurwitz, B.J., Waldmann, T.A., Poiesz, B.J.: Detection of exogenous sequences homologous to human retroviral DNA in Multiple Sclerosis by gene amplification. Proc. Natl. Acad. Sci. (USA) 86:2878-2882, 1989. |
| 28. |
|
Ehrlich, G.D.*, Glaser J., Lavigne, K., Quan, D., Mildvan, D., Sninsky, K., Papsidero, L., and Poiesz, B.J.: Prevalence of Human T-Cell Leukemia/Lymphoma Virus Type II Infection Among High Risk Individuals: Type-Specific Identification of HTLVs by Polymerase Chain Reaction. Blood 74:1658-1664, 1989. |
| 29. |
|
Papsidero, L., Swartzwelder, F., Sheu, M., Montagna, R., Ehrlich, G.D. and Poiesz, B.J. Immunodetection of HTLV-I Core Protein in Biological Samples Using a Monoclonal Antibody Immunoassay. J. Clin. Microbiol. 28:949-955, 1990. |
| 30. |
|
Greenberg, S., Jaffe, E., Ehrlich, G.D., Korman, N., Poiesz, B., Waldmann, T.: Kaposi's Sarcoma in human T-cell leukemia virus type I-associated adult T-cell leukemia. Blood 76:971-976, 1990. |
| 31. |
|
Gendelman, H.E., Ehrlich, G.D., Bala, L.M., Conley, S., Ribas, J., Kahen, D.C., Meltzen, M.S., Poiesz, B.J., Nara, P.N.: Lack of evidence for protective human immunodeficiency virus infection in chimpanzee monocytes: a unique restricted tropism correlating with lack of disease. J. Virol. 65:3853-3863, 1991 |
| 32. |
|
Graziano, S.L., Pfeifer, A.M., Testa, J.R., Hallinan, E.J., Mark, G.E., Johnson, B.E., Pettersill, O.S., Tatum, A.H., Brauch, H., Zbar, B., Flejter, W.L., Ehrlich, G.D., Poiesz, B.J.: Involvement of the c-Raf-1 locus, at band 3p25, in the detection of small cell lung cancer. Genes, Chromosomes and Cancer 3:283-293, 1991. |
| 33. |
|
Sullivan, M.T., Williams, A.E., Chyang, F.T., Grandinetti, T., Poiesz, B.J., Ehrlich, G.D., and The American Red Cross HTLV-I/II Collaborative Study Group: Transmission of HTLV-I and HTLV-II to prior recipients of blood products from HTLV-I/II seropositive donors. Archives of Int. Med. 151:2043-2048, 1991. |
| 34. |
|
Shankarappa, B., Sirko, A., Ehrlich, G.D.*: A general method for the identification of regions suitable for site-directed silent mutagenesis. Biotechniques 12:382-384, 1992. |
| 35. |
|
Ehrlich, G.D.*, Andrews, J.S., Sherman, M.P., Greenberg, S.J., Poiesz, B.J. Analysis of the HTLV-I P21e transmembrane protein gene reveals inter and intra-isolate genetic heterogeneity. Virology 186:619-627, 1992. |
| 36. |
|
Sherman, M.P., Ehrlich, G.D., Ferrer, J.F., Sninsky, J.J., Zandomeni, R., Dock, V.L., Poiesz, B.J.: Amplification and analysis of specific DNA and RNA sequences of the bovine leukemia virus from infected cows by the polymerase chain reaction. J. Clin. Microbiol. 30:185-191, 1992. |
| 37. |
|
Shankarappa, B., Balachandran, R., Gupta, P., and Ehrlich, G.D.*: Introduction of multiple restriction enzyme sites by in vitro mutagenesis using the polymerase chain reaction. PCR Methods and Applications 1:277-278, 1992. |
| 38. |
|
Shankarappa, B., Vijayananda, K., and Ehrlich, G.D.*: SILMUT: A computer program for the identification of regions suitable for silent mutagenesis to introduce restriction enzyme recognition sequences. Biotechniques 12:882-884, 1992. |
| 39. |
|
Sullivan, M.T., Williams, A.E., Fang, C.T., Notari, E.P., Poiesz, B.J., Ehrlich, G.D., and the American Red Cross HTLV-I/II Collaborative Study Group: HTLV-I and HTLV-II infection in sexual contacts and family members of sero positive blood donors who are seropositive for HTLV-I and II. Transfusion 33:585-590, 1993. |
| 40. |
|
Mateo, R., Demetris, A., Sico, E., Frye, C., Wang, L.-F., El-Sakhawi, Y., Reilly, M., Ehrlich, G.D., Cooper, D., and Fung, J. Early detection of denovo hepatitis C infection in patients after liver transplantation by reverse transcriptase polymerase chain reaction. Surgery 114:442-448, 1993. |
| 41. |
|
Randhawa, P.S., Jaffe, R., Rinaldo, C., Jr., Ho, M., Demetris, A.J., Manez, R., Kusne, S., and Ehrlich, G.D.*: Detection of cytomegalovirus in formalin fixed paraffin embedded donor, native and allograft liver tissue using a multiplex PCR-LH assay. Modern Pathology 7:125-128, 1994. |
| 42. |
|
Wadowsky, R.M., Laus, S., Liebert, T., States, S.T., and Ehrlich, G.D.: Inhibition of a PCR-based assay for Bordatella pertussis by calcium alginate. Fiber and aluminum-shaft components of a naso-pharyngeal swab. J. Clin. Microbiol. 32:1054-1057, 1994. |
| 43. |
|
Dosik, H., Goldstein, M.F., Poiesz, B.J., Williams, L., Fahnrich, B., Ehrlich, G.D., Dunn, I., and Levine, P.H. Seroprevalence of human T-lymphotropic virus in blacks from a selected central Brooklyn population. Cancer Invest. 12:289-295, 1994. |
| 44. |
|
Boldt-Houle, D.M., Nigida, S.M., Jr., Rinaldo, C.R., Jr., and Ehrlich, G.D. The T-cell receptor V- repertoire in naive and human immunodeficiency virus-1 (HIV-1) infected chimpanzees. J. Med. Primatol. 23: 241-250, 1994. |
| 45. |
|
Randhawa, P.S., Manez, R., Frye, B., and Ehrlich, G.D. Circulating immediate early (IE) mRNA in patients with cytomegaloviral infections after solid organ transplantation. J. Infect. Dis. 170:1264-1267; 1994. |
| 46. |
|
Bailer, R.T., Lazo, A., Harisdangkul, V., Ehrlich, G.D., Gray, L.S., Whisler, R.L., and Blakeslee, J.R. Lack of evidence for human T-Cell Lymphotrophic virus type I or II infection is systemic lupus erythematosus or rheumatoid arthritis patients. J. Rheumatol. 21:2217-2224; 1994. |
| 47. |
|
Sherman, M.P., Dock, N.L., Ehrlich, G.D., Sninsky, J.J., Brothers, C., Gilsdorf, J., Bryz-Gornia, V., and Poiesz, B.J. Evaluation of HIV-1 western blot indeterminate blood donors for the presence of human or bovine retroviruses. AIDS Res. Hum. Retrovirus 11:409-414; 1995. |
| 48. |
|
Zhang, Y., Issacman, D., Wadowsky, R.M., Rydquist-White, J., Post, J.C., Ehrlich, G.D.* Detection of Streptococcus pneumoniae in whole blood by PCR. J. Clin. Microbiol. 33:546-601; 1995. |
| 49. |
|
Post, J.C., Preston, R.A., Aul, J.J., Larkins-Pettigrew, M., Rydquist-White, J., Anderson, K.W., Wadowsky, R.M., Doyle, W.J., Reagan, D.R., Walker, E.S., Kingsley, L.A., Magit, A.E., Ehrlich, G.D.* Molecular analysis of bacterial pathogens in otitis media with effusion. JAMA 273:1598-1604; 1995. |
| 50. |
|
Laifer, S.A., Ehrlich, G.D., Huff, D., Balsam, M., and Scantlebury, V. Congenital cytomegalovirus infection in offspring of liver transplant recipients. Clin. Infect. Dis. 20:52-55; 1995. |
| 51. |
|
Issacman, D.J., Zhang, Y., Rydquist-White, J., Wadowsky, R.M., Post, J.C., and Ehrlich, G.D. Identification of a patient with Streptococcus pneumoniae bacteremia and meningitis by the polymerase chain reaction. Cell. Molec. Probes 9:157-160; 1995. |
| 52. |
|
Pou, A.M., Rimell, F.L., Jordan, J.A., Shoemaker, D.L., Johnson, J.T., Barua, P., Post, J.C., Ehrlich, G.D. Adult respiratory papillomatosis: Human papilloma virus (HPV) type and viral coinfections as predictors of prognosis. Ann. Otol. Rhinol. & Laryngol 104: 758-762; 1995. |
| 53. |
|
Buchman, C.A., Doyle, W.J., Skoner, D.P., Post, J.C., Alper, C.M., Seroky, J.T., Anderson, K., Preston, R.A., Hayden, F., Fireman, P., and Ehrlich, G.D. Influenza A virus-induced acute otitis media. J. Infect. Dis. 172: 1348-1351;1995. |
| 54. |
|
Post, J.C., Aul, J.J., White, G.J., Wadowsky, R.M., Zavoral, T., Tabari, R., Kerber, B., Doyle, W.J., and Ehrlich, G.D.* PCR-based detection of bacterial DNA after antimicrobial treatment is indicative of persistent, viable bacteria in the chinchilla model of otitis media. Am. J. Otolaryngol. 7:1-7;1996. |
| 55. |
|
Post, J.C., White, G.J., Aul, J.J., Zavoral, T., Wadowsky, R.M., Preston, R.M., Ehrlich, G.D.* Development and validation of a multiplex PCR-based assay for the upper respiratory tract bacterial pathogens, Hemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis. Mol. Diagnosis 1: 29-39;1996. |
| 56. |
|
Mañez, R., Kusne, S., Aguado, J.M., St. George, K., Grossi, P., Frye, B., Rinaldo, C., Ehrlich, G. The time of infection after transplantation is the best predictor of disease progression in CMV-seronegative liver recipients of CMV-seropositive allograft. J. Infect. Dis. 173: 1072-6, 1996. |
| 57. |
|
Koehler, M., St. George, K., Ehrlich, G.D., and Rinaldo, C. The utility of CMV DNA PCR in peripheral blood of BMT recipients at high risk for CMV disease. Bone Marrow Transplantation (letter) 17: 465-466, 1996. |
| 58. |
|
Post, J.C., Mulvihill, J.J., Ehrlich, G.D. A report on the International Genetic Workshop on Crouzon and other Craniofacial Disorders, March 10-11, 1995. Archives Otolaryngol 122: 576-578, 1996. |
| 59. |
|
Ehrlich, G.D.*, and Post, J.C. Bacterial DNA in middle-ear effusions. JAMA 275: 186, 1996. |
| 60. |
|
Sirko, D.A. and Ehrlich, G.D.* Genotypic and Phenotypic Characterization of a Neutralization Resistant Breakthrough Population of HIV-1. Virology 218: 238-242, 1996. |
| 61.& |
|
Chen, Y. and Ehrlich, G.D.* Comparative analysis of three nucleic acid-based detection systems for hepatitis C virus RNA in plasma from liver transplant recipients. Cellular and Molecular Probes 10: 331-336, 1996. |
| 62. |
|
Moschones, N.K., Sporr, N.K., Mao, J., and the Chromosome 10 Workshop Participants. First International Workshop on Human Chromosome 10 Mapping. Cytogenet. Cell Genet. 72: 99-112, 1996. |
| 63. |
|
Post, J.C., Aul, J.J., White, G.J., Wadowsky, R.D., Doyle, W.J., Fireman, P., Skoner, D.P., Buchman, C.A., and Ehrlich, G.D.* PCR detection of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis via a multiplex assay following an influenza A virus challenge of the human nasopharynx. Proceedings of the 6th International Symposium on Recent Advances in Otitis Media. B.C. Decker, Inc., pp. 421-422, 1996. |
| 64. |
|
Ehrlich, G.D., Aul, J.J., White, G.J., Zaworal, T.W., Jr., Kerber, B., Tabari, R., Wadowsky, R.D., Doyle, W.J., and Post, J.C. Persistence of DNA in Middle-ear effusions of chinchillas as determined by the PCR. Proceedings of the 6th International Symposium on Recent Advances in Otitis Media. B.C. Decker, Inc., pp. 253-256, 1996. |
| 65. |
|
Kenna, M.A.., White, G., Wadowsky, R.D., Post, J.C., and Ehrlich, G.D. Bacteriology of otorhea: polymerase chain reaction versus culture. Proceedings of the 6th International Symposium on Recent Advances in Otitis Media. B.C. Decker, Inc., pp. 428-430, 1996. |
| 66. |
|
Liederman, E.M., Post, J.C., Aul, J.J., Sirko, D.A., White, G.J., Buchman, C.A., and Ehrlich, G.D.* Analysis of Adult Otitis Media: Polymerase Chain Reaction versus Culture for Bacteria and Viruses. Annals of Otology, Rhinology, and Laryngology 107:10-16, 1998. |
| 67. |
|
Boldt-Houle, D.M., Jamieson, B.D., Aldrovandi, G.M., Rinaldo, C.R., Jr., Ehrlich, G.D., and Zack, J.A. Loss of T cell receptor V- repertoire in HIV-1 infected SCID-hu mice. AIDS Research and Human Retroviruses 13: 125-134, 1997. |
| 68. |
|
Wadowsky, R.M., Michaels, R.H., Libert, T., Kingsley, L.A., and Ehrlich, G.D. Multiplex Polymerase Chain Reaction-Based Assay for the Detection of Bordetella Pertussis in Nasopharyngeal Swab Specimens. J. Clin. Microbiol. 34: 2645-2649, 1996. |
| 69. |
|
Kusne, S., Mañez, R., Frye, B.L., St. George, K., Abu-Elmagd, K., Tabasco-Menguillon, J., Fung, J.J., Todo, S., Rinaldo, C. and Ehrlich, G.D.* Use of DNA amplification for diagnosis of cytomegalovirus enteritis after intestinal transplantation. Gastroenterology 112: 1121-1128, 1997. |
| 70. |
|
Koehler, M., St. George, Kirsten, Ehrlich, G.D., Mirro, J., Jr., Neudorf, S.M., and Rinaldo, C.R. Prevention of CMV Disease in Allogenic BMT Recipients by Cytomegalovirus Antigenemia-Guided Preemptive Ganciclovir Therapy. Journal of Pediatric Hematology Oncology 19(1):43-47, 1997. |
| 71. |
|
Sossenheimer, M.J., Aston, C.E., Preston, R.A., Gates, L.K., Ulrich, C.D., Martin, S. P., Zhang, Y., Gorry, M.C., and Ehrlich, G.D., and Whitcomb, D.C. Clinical characteristics of hereditary pancreatitis in a large family based on high-risk haplotype. American Journal of Gastroenterology Vol. 92, No. 7, 1997. |
| 72. |
|
Michael, M.G., Alcendor, D.J., St. George, K., Rinaldo, C.R., Ehrlich, G.D., Becich, M.J., and Hayward, G.S.Distinguishing baboon cytomegalovirus from human cytomegalovirus importance for xenotransplantation. Journal of Infectious Disease 176:1476-83, 1997. |
| 73. |
|
Rimell, F.L., Shoemaker, D.L., Pou, A.M., Jordan, J.A., Post, J.C., and Ehrlich, G.D. Analysis of pediatric respiratory papillomatosis: prognostic role of viral typing and co-factors Laryngoscope 107:915-918, 1997. |
| 74. |
|
Marshall DJ, Heisler LM, Lyamichev V, Murvine C, Olive DM, Ehrlich G.D., Neri BP, de Arruda M. Determination of hepatitis C virus genotypes in the United States by cleavase fragment length polymorphism analysis. J Clin Microbiol 35:3156-62. 1997 |
| 75. |
|
Aul, J.J., Anderson, K.W., Kerber, B., Wadowsky, R., Doyle, W.J., Kingsley, L.A., Post, J.C., Ehrlich, G.D.* A comparative evaluation of culture and PCR for the detection and determination of persistence of bacterial strains and DNAs in the Chinchilla laniger model of otitis media. Annals of Otology, Rhinology and Laryngology 107:508-513, 1998. |
| 76. |
|
Rayner, M.G., Zhang, Y., Gorry, M.C., Chen, Y., Post, J.C., and Ehrlich, G.D.* Evidence of bacterial metabolic activity in culture-negative otitis media with effusion. JAMA 279:296-299, 1998. Abstracted in Molecular Medicine 4:141, 1998. |
| 77. |
|
Bakaletz, L.O., White, G.J., Post, J.C., and Ehrlich, G.D. Blinded multiplex PCR analyses of middle ear and nasopharyngeal fluids from chinchilla models of single and mixed pathogen induced otitis media. Clinical and Diagnostic Laboratory Immunology 5(2): 219-224, 1998. |
| 78. |
|
!Isaacman, D.J., Zhang, Y., Reynolds, E.A., Ehrlich, G.D. Utility of a polymerase chain reaction-based assay for detection of Pneumococcal Bacteremia in children. Pediatrics 101, No.5:813-816, 1998. |
| 79. |
|
Shankarappa, B., Gupta, P., Learn, G.H., Jr., Rodrigo, A.G., Rinaldo, C.R., Jr., Gorry, M.C., Mullins, J.I., Nara, P.L., and Ehrlich, G.D.* Evolution of Human Immunodeficiency Virus Type I Envelope Sequences in Infected Individuals with Differing Disease Progression Profiles. Virology 241:251-259,
1988. |
| 80. |
|
Rossi, L, Whitcomb, D.C., Ehrlich, G.D., Gorry, M.C., Parvin, S., Sattar, S, Ali, L., Azad-Khan, A.K., Gyr, N. Lack of R117H mutation in the cationic trypsinogen gene in patients with tropical pancreatitis from Bangladesh. Pancreas 17:278-80. 1998 |
| 81. |
|
Duerr, R.H., Barmada, M.M., Zhang, L., Davis, S., Preston, R.A., Chevany, L.J., Brown, I.L., Ehrlich, G.D., Weeks, D.E., Aston, C.E. Linkage and association between inflammatory bowel disease and a locus on chromosome 12. Am J Hum Genet. 63:95-100. 1998. |
| 82. |
|
Walker, E.S., Post, J.C., Preston, R.A., and Ehrlich, G.D. Genetic diversity of Moraxella catarrhalis using multiple DNA probes and single-locus PCR-RFLP. J. Clin. Microbiol. 36, No. 7:1977-1983, 1998. |
| 83. |
|
Dingman, J.R., Rayner, M.G., Mishra, S., Zhang, Y. Post, J.C., and Ehrlich, G.D.* Correlation between presence of viable bacteria and presence of endotoxin in middle-ear effusions. J. Clin Microbiol.36:3417-3419, 1998. |
| 84. |
|
¥Zhang, Y., Gorry, M.C., Post, J.C., and Ehrlich, G.D.* Genomic Organization of the Human Fibroblast Growth Factor Receptor 2 (FGFR2) Gene and Comparative Analyses of the Human FGFR Gene Family. Gene 230:69-79, 1999. |
| 85. |
|
Ozen, R.S., Baysal, B.E., Devlin, B., Farr, J.E., Gorry, M., Ehrlich, G.D., Oour, G. and Richard, C.W. Fine mapping of the split hand-split foot (SHFM3) locus at 10q24: Evidence for anticipation and segregation distortion. American Journal of Human Genetics 64:1646-1654,1999. |
| 86. |
|
Glustein JZ, Zhang Y, Wadowsky RM, Ehrlich GD. 1999. Development of a simplex polymerase chain reaction-based assay for the detection of Neisseria meningitidis. Mol Diagn 4:233-40. |
| 87. |
|
Poiesz, B.J., Papsidero, L.D., Ehrlich, G.D., Sherman, M., Dillon, K., Ruscetti, F.W., Slamon, D., Fang, C., Williams, A., Duggan D., Glaser, J., Gottlieb, A., Goldberg, J., Ratner, L., Phillips, P., Han, T., Friedman-Kien, A., Siegal, F., Rai, K., Sawitsky, A., Sninsky, J., Cunningham, C., and Montagna R. The prevalence of Human T-cell Leukemia Virus Types I and II in various patient populations, retroviral risk groups and healthy blood donors. American Journal of Hematology 66: 32-38, 2001. |
| 88. |
|
Darden, D.L., Hu, Fen Ze, Gorry, M.C., Dressman, D., Li, H.S., Whitcomb, D.C., Dohar, J., Ehrlich, G.D.* RNA differential display of scarless wound healing in fetal rabbit indicates downregulation of a CCT chaperonin subunit and upregulation of a glycophorin-like gene transcript. Journal of Pediatric Surgery 2000 35:406-19. |
| 89. |
|
Dry, G.M., Yasinskaya Y.I., Williams, J.K., Ehrlich, G.D., Preston, R.A., Hu, F.Z., Gruss, J.S., Ellenbogen, R., and Cunningham, M.L. Inhibition of apoptosis: a potential mechansim for syndromic craniosynostosis. Plastic and Reconstructive Surgery 107:425-32, 2001. |
| 90. |
|
Garth D. Ehrlich*, Howard J. Hoffman, H. Ronald Zielke, Gregory J. White, Fen Ze Hu, Robert Vigorito, Jeffrey R. Dingman, Therese Libert, John E. Smialek, and J. Christopher Post. Molecular epidemiological studies of common bacterial and viral respiratory pathogens in sudden infant death syndrome (SIDS). Proceedings of the 7th International Symposium on Recent Advances in Otitis Media (In Press) 2002 |
| 91. |
|
+Hu F.Z., Preston R.A., Post J.C., White J.G., Kikuchi L., Wang X., Self T.W., Allen G., Stiffler R.S., McGraw C., Pulsifer-Anderson E.A., and Ehrlich, G.D.* Mapping of a gene for pediatric gastroesophageal reflux to chromosome 13q: a collaboration with a family self-help group. JAMA 284: 325-334, 2000. |
| 92. |
|
Li, H. S., Hebda, P.A., Kelly L.A., Ehrlich, G.D., Whitcomb, D.C., and Dohar J.E. Prostaglandin EP4 receptor mRNA is upregulated in fetal rabbit skin wound. Arch Otolaryngol Head Neck Surg. 126(11):1337-43, 2000. |
| 93. |
|
Amann, S.T., Gates, L.K., Preston, R.A., Gorry, M.C., Aston, C.E., Ehrlich, G.D., and Whitcomb, D.C. Nonpenetrance of the Hereditary Pancreatitis Phenotype may be Independent of Genotype: A Study of Monozygotic Twins. (In press). |
| 94. |
|
Hu, F.Z., Post, J.C., Johnson, S., Ehrlich, G.D., and Preston, R.A. Reduction of the GER gene region on 13q 14 and exclusion of the 5-HT2A Receptor Gene as cause of Hereditary Severe Pediatric Gastroesophageal Reflux. Human Genetics. 107:519-25, 2000. |
| 95. |
|
Ehrlich, G.D.*, Hu, F.Z., Preston, R.A., and Post, J.C. The Spectrum of Pediatric Gastroesophageal Reflux. (letter) JAMA. 284:3125. 2000. |
| 96. |
|
Heike, C., Seto, M., Ehrlich, G.D., Preston, R.A., Hu, F.Z., Hing, A., Jackson, C., Palidin, A., Cunningham, M. A Centruy of Jackson-Weiss Syndrome: Further Definition of Clinical and Radiographic Findings in 'Lost' Descendants of the Original JWS Kindred. American Journal of Medical Genetics. 100:315-324, 2001. |
| 97. |
|
Sauer, K., Camper, A.K., Ehrlich, G.D., Costerton, J.W., and Davies, D.G. Pseudomonas aeruginosa Displays Multiple Phenotypes during Development of a Biofilm. Journal of Bacteriology 184:1140-1154, 2002. |
| 98. |
|
°Ehrlich, G.D.*, Veeh, R., Wang, X., Costerton, J.W., Hayes, J.D., Hu, F.Z., Daigle, B.J., Ehrlich, M.D., Post, J.C. Mucosal Biofilm Formation on Middle-ear Mucosa in the Chinchilla Model of Otitis Media. JAMA 287:1710-1715, 2002. |
MANUSCRIPTS SUBMITTED AND IN PREPARATION |
| 99. |
|
Dunne, M.W., Ehrlich, G.D., Hu, F.Z., Khurana, C., Arguedas, M.A., Rodrigues, A., Arrieta, A., McLinn, S., Krogsatd, J.A., Blattner, M., Schwartz, R., Emparanza, P., Gooch III, W., Aspin, M., Podgore, J., Roine, I., Blumer, J., Johnson, S., Hayes, J., and Chow, J. Treatment of Acute Otitis media with a Single Dose of Azithromycin: Clinical Outcome by Bacterial Pathogen Diagnosed by Either Culture or Polymerase Chain Reaction. (submitted) |
| 100. |
|
Dunne, M.W., Khurana, C., Arguedas, M.A., Rodrigues, A., Arrieta, A., McLinn, S., Krogsatd, J.A., Blattner, M., Schwartz, R., Vargas. S., Emparanza, P., Fernandez , P., Gooch III, W., Aspin, M., Podgore, J., Roine, I., Blumer, J., Ehrlich, G.D.and Chow, J. Microbiologic and Clinical Efficacy of Single Dose Azithromycin in the Treatment of Acute Otitis Media (submitted) |
| 101. |
|
Erdos, G., Sayeed, S., Antalis, P., Hu, F.Z., Hayes, J., Goodwin, J., Dopico, R.J., Post, J.C., and Ehrlich, G.D. Development and Characterization of a Pooled Haemophilus influenzae Genomic Library for the Evaluation of Gene Expression Changes Associated with Mucosal Biofilm Formation (submitted) |
| 102. |
|
Garth D. Ehrlich, Geza Erdos, Fen Ze Hu, Patty Antalis, Sameera Sayeed, Kai Shen, Xue Wang, Jay Hayes, Rick Veeh, William J. Costerton, J. Christopher Post. Pathogens Utilize a Distributed Genome as a Supra-Virulence Factor (In preparation). |
| 103. |
|
Glaser, J.B., Ehrlich, G.D., Elsayegh, S., Greifinger, R., Dube, D.K., Benz, P., Dube, S., Atwood, S., Cummings, T., and Poiesz, B.J. HTLV-II coinfection among HIV-1 infected prison inmates (Submitted) |
| 104. |
|
F.Z. Hu, A. Nyström, A. Ahmed, R. Dopico, I. Mossberg, M. Palmquist, J. Gladitz, M. Rayner, J.C. Post, R.A. Preston, and G.D. Ehrlich. Mapping a Gene for Dupuytren contracture to chromosome 16 in two Swedish families. (In preparation) |
| 105. |
|
Zhang, Y., and Ehrlich, G.D.* Characterization of the human fibroblast growth factor receptor 2 gene promoter. (In preparation). |
| 106. |
|
Krakora, S., Pollice A., Cunningham M.L., Ornitz D., Post, J. C. and Ehrlich, G.D.* Mutant FGFR2-induced Down Regulation of Apoptosis in Osteoblasts as a mechanism of cranial synostosis (In Preparation) |
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Corresponding author |
| + |
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Accompanied by highlighting editorial |
| # |
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Selected for abstracting in Abstracts International |
| & |
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Selected for electronic reproduction by Simstar Digital Media |
| o |
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Indexed in DNA probes |
| $ |
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Abstracted in "Internal Medicine News" and "Family Practice News" |
| @ |
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Selected by Quantum Chemistry Program Exchange for worldwide distribution; indexed in GIBCO/BLL catalog, indexed in New England Biology Catalogue. |
| ^ |
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Accompanied by University of Pittsburgh Medical Center and Children's Hospital of Pittsburgh Press Release. |
| ! |
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Lead Article |
| ¥ |
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Indexed in Protein Research Database |
| ° |
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Reviwed in Boston Globe, Pittsburgh Post Gazette, Pitsburgh Tribune Review, Pulmonary Reviews, and Biophotonic Intl Magazine etc |
Genebank DNA Sequence Submissions
| 1. |
|
Whitcomb, D.C., Gorry, M.C., Preston, R.A., Furey, W., Sossenheimer, M.J., Ulrich, C.D., Martin, S.P., Gates, L., Amann, S.T., Toskes, P.P., Liddle R., McGrath, K., Uomo, G., Post, J.C., and Ehrlich, G.D. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. |
| 2. |
|
MCU73324-Walker, E.S., Preston, R.A., Post, J.C., Ehrlich, G.D., and Klingman, K.L. Moraxella catarrhalis glycyl-tRNA synthetase-subunit (GlyRS) and NAD repressive NMN transportor NADRp (NadR) genes, partial cds, and glycyl-tRNA synthetase-subunit (GlyRS) gene, complete cds (3725 bp) 11/4/96. |
(This section has not been updated recently)
Books
| B-1 |
|
Ehrlich, G.D., and Greenberg, S.J.: PCR-Based Diagnostics In Infectious Disease. Boston: Blackwell Scientific Publications, 1994, 697 pages (Textbook and Laboratory Manual)-on Blackwell's Best Seller List. |
Monographs Edited
| J-1 |
|
Adams, D. and Ehrlich, G.D. International Clinical Practice Series. Otitis Media-Prospects for Management. Kent: Wells Medical Limited, 1996. |
Invited and Contribued Chapters
| C-1 |
|
Poiesz, B.J., Moore, J.L., Merl, S.A., Tomar, R.H., Zamkoff, K.W., Davey, F.R., Planas, A.T., Gottlieb, A.J., Runge, L.A., Cowan, B.Y., Reeves, W.G., Ehrlich, G.D., Ruscetti, F.W., Han, T., Cabradillo, C.D., and Comis, R.L. Biology and Epidemiology of Human T-cell Leukemia/Lymphoma Virus, 1984. |
| C-2 |
|
Ehrlich, G.D.: Correlation of molecular and clinical parameters of human T-lymphotropic retroviral infections, Ph.D. Dissertation, University Microfilms, 1987. |
| C-3 |
|
Ehrlich, G.D. and Poiesz, B.J. Clinical and molecular parameters of HTLV-I infection. In: Clinics in Laboratory Medicine (eds. Davey, F. and Saunders, W.B.) 8:65-84, 1988. |
| C-4 |
|
Poiesz, B.J., Ehrlich, G.D., Papsidero, L., and Sninsky, J.J. Detection of Human Retroviruses. In: AIDS: Etiology, Diagnosis, Treatment and Prevention 2nd edition, (eds. Devita, V., Hellman, S., Rosenberg, S., Lippincott) 137-154, 1988. |
| C-5 |
|
Kwok, S., Mack, D., Ehrlich, G.D., Poiesz, B., Dock, N., Alter, H., Mildvan, D., Grieco, M., and Sninsky, J. Enzymatic amplification of HIV viral sequences in peripheral blood mononuclear cells: HIV detection by genetic engineering methods, (eds. Luciw, P.A. and Steimer, K.S., Marcel Dekker, Inc. New York) 243-255, 1988. |
| C-6 |
|
Ehrlich, G.D. The biology and spectrum of disease associated with human retroviruses. (Requested Seminars in Neurology). |
| C-7 |
|
Poiesz, B.J., Ehrlich, G.D., Byrne, B.C., Abbott, M., Kwok, S., and Sninsky, J.J. Use of PCR in the detection, quantification and characterization of human retroviruses. In: Current Communications in Molecular Biology: Polymerase Chain Reaction. Cold Spring Harbor Press, Cold Spring Harbor; pp 159-164, 1989. |
| C-8 |
|
Ehrlich, G.D., Greenberg, S. and Abbott, M. Detection of human T-cell lymphoma/leukemia viruses (HTLV). Chapter 39, In: PCR Protocols: A Guide to Methods and Applications (eds. Innis, M.A., Gelfand, D.H., Sninsky, J.J., White, T.J.). Academic Press, San Diego; 325-336, 1990. |
| C-9 |
|
Ehrlich, G.D., Abbott, M.A., Hurwitz, B.J., Waldman, T.A., Poiesz, B.J., Greenberg, S.J. Evidence for homologous retroviral sequences in multiple sclerosis by enzymatic gene amplification. In: UCLA Symposia on Molecular and Cellular Biology: Early Human Retroviruses. New Series, Vol. 119: (eds. Groopman, J.E., Chen, I., Essex, M., and Weiss, R. New York: Alan R. Liss, Inc.) 1990; pp. 373-382. |
| C-10 |
|
Poiesz, B.J., Ehrlich, G.D., Byrne, B., Wells, K., Kwok, S., Sninsky, J.: The Use of the PCR in the Detection, Quantification and Characterization of Human Retroviruses. In: Medical Virology IX (eds. Delamaza, I.M. and Peterson, E.M.). Plenum Press, New York, NY; pp. 47-75, 1990. |
| C-11 |
|
Ehrlich, G.D.: Utilization of PCR-Based Technology: Retroviral Pathogenesis Studies. In: Clinical Chemistry 37:609-610, 1991. |
| C-12 |
|
Ehrlich, G.D., and Sirko, D.A.: The Polymerase Chain Reaction and its role in Clinical Diagnostics. In:-PCR-Based Diagnostics in Infectious Disease (eds. Ehrlich, G.D. and Greenberg, S.J.). Blackwell Scientific Publications, Boston; 3-18, 1994. |
| C-13 |
|
Sirko, D.A. and Ehrlich, G.D.: PCR Laboratory Facilities, Protocols and Operations. In: PCR-Based Diagnostics in Infectious Disease (eds. Ehrlich, G.D. and Greenberg, S.J.). Blackwell Scientific Publications, Boston; 19-44, 1994. |
| C-14 |
|
Ehrlich, G.D. and Sirko, D.A.: Parameters for Maximizing the Sensitivity and Specificity of the Polymerase Chain Reaction. In: PCR-Based Diagnostics in Infectious Disease (eds. Ehrlich, G.D. and Greenberg, S.J.). Blackwell Scientific Publications, Boston; 45-56, 1994. |
| C-15 |
|
Greenberg, S.J., and Ehrlich, G.D.: Introduction to PCR for Pathogenic Organisms for Specific Organ Systems. In: PCR-Based Diagnostics in Infectious Disease (eds. Ehrlich, G.D. and Greenberg, S.J.). Blackwell Scientific Publications, Boston; 133-136,1994. |
| C-16 |
|
Magit, A., Ehrlich, G.D., Post, J.C.: Applications of the Polymerase Chain Reaction to the Diseases of the Ear, Nose and Throat. In: PCR-Based Diagnostics in Infectious Disease (eds. Ehrlich, G.D. and Greenberg, S.J.). Blackwell Scientific Publications, Boston; 193-212, 1994. |
| C-17 |
|
Ehrlich, G.D.: Laboratory Protocols for the PCR-based Detection of Infectious Disease Agents. In: PCR-Based Diagnostics in Infectious Disease (eds. Ehrlich, G.D. and Greenberg, S.J.). Blackwell Scientific Publications, Boston; 335-340, 1994. |
| C-18 |
|
Mateo, R., Faruki, H., Cooper, D., Demetris, A.J., Ehrlich, G.D.: Detection of Hepatitis C Virus RNA in Liver and Plasma by RT-PCR-Liquid Hybridization. In: PCR-Based Diagnostics in Infectious Disease (eds. Ehrlich, G.D. and Greenberg, S.J.). Blackwell Scientific Publications, Boston; 375-398, 1994. |
| C-19 |
|
Ehrlich, G.D.: PCR-Based Laboratory Methods for the Detection of the Human Retroviridae and Hepadnaviridae. In: PCR-Based Diagnostics in Infectious Disease (eds. Ehrlich, G.D. and Greenberg, S.J.). Blackwell Scientific Publications, Boston; 415-446, 1994. |
| C-20 |
|
Post, J.C., Pettigrew, M., Magit, A.E., Ehrlich, G.D., Bernstein, J., Greenberg, S.J., Glenister, N., and Evans, M.J.: PCR-based Strategies for the Detection of Hemophilus influenzae and Streptococcus pneumoniae DNA Associated with Diseases of the Ears, Nose and Throat. In: PCR-Based Diagnostics in Infectious Disease (eds. Ehrlich, G.D. and Greenberg, S.J.). Blackwell Scientific Publications, Boston; 593-608. |
| C-21 |
|
Wadowsky, R.M., Libert, T., Ehrlich, G.D.: Detection of Bordatella pertussis by PCR. In: PCR-Based Diagnostics in Infectious Disease (eds. Ehrlich, G.D. and Greenberg, S.J.). Blackwell Scientific Publications, Boston; 621-632, 1994. |
| C-22 |
|
Chen, Y., and Ehrlich, G.D.: Organization and Structure y a Modern Molecular Diagnostics Lab Orienting. In: Clinical Diagnostic Immunology (eds Nakarmua, R.M., Burek, C.L., Cook, L., Folds, J.D., and Sever, J.L.) Blackwell Science: Boston (In Press). |
| C-23 |
|
Zhang, Y., and Ehrlich, G.D.: Molecular Assays for Infectious Diseases and Syndromes. In: Clinical Diagnostic Immunology (eds Nakarmua, R.M., Burek, C.L., Cooh, L., Folds, J.D., and Sever, J.L) Blackwell Science: Boston (In Press). |
| C-24 |
|
Post, J.C. and Ehrlich, G.D.: Otologic disorders in the HIV-Positive Child. In: Grundfast K, Lalwani AK (eds). Pediatric Otology & Neurotology. Philadelphia: Lippicott, Raven, pp. 479-485, 1998. |
| C-25 |
|
Shen, K., Post, J.C., and Ehrlich, G.D.: Molecular and Translational Research Approaches for the study of Bacterial Pathogenesis in Otitis Media. In: Rosenfeld, R., and Bluestone, C.D. (eds). Evidence-based Otitis Media, 2nd Edition. Hamilton: B.C. Decker Inc. (In prepartion) (2003) |
Abstracts
Posters and Slide Presentations |
| A-1. |
|
Poiesz, B., Moore, J., Merl, S., Tomar, R., Zamkoff, K., Davey, F., Planas, A., Gottlieb, A., Runge, L., Cowan, B., Reeves, W., Ruscetti, F., Han, T., Cabradillo, C., Ehrlich, G.D., and Comis, R.: Biology and epidemiology of HTLV. Cold Spring Harbor Laboratory Press, 237-247, 1984. (Oral Presentation) |
| A-2. |
|
Poiesz, B., Zamkoff, K., Merl, S., Moore, J., Davey F., Tomar, R., Ehrlich, G.D., Comis, R., Gottlieb, A., and Goldberg, J. Detection of anti-HTLV antibodies and HTLV proteins in patients with myelomonocytic leukemia. Blood 62:108a, 1983. |
| A-3. |
|
Ehrlich, G.D., Moore, J., Tomar, R. et. al.: Integrated HTLV proviral DNA in the splenocyte of a patient with AIDS. J. Cell. Biochem. (Suppl). 8A:1, 1984). |
| A-4. |
|
Poiesz, B., Tomar, R., Merl, S., Moore, J., Kloster, B., Planas, A., Han, T., Cabradillo, C., Ehrlich, G.D., Comis, R., and Gottlieb, A.: Detection of human T-cell lymphoma/leukemia virus (HTLV) in patients with acquired immunodeficiency (AIDS) or generalized lymphadenopathy syndrome (GLS). Blood 62:1151, 1983. |
| A-5. |
|
Ehrlich, G.D., Blair, D., Kloster, B., et. al.: HTLV-I homologous sequences in fresh and cultured cells from AIDS and ARC patients. Cold Spring Harbor RNA Tumor Virus Meeting. 1984. |
| A-6. |
|
Poiesz, B., Tomar R., Ehrlich, G.D., Merl, S., Moore, J., Planas, A., Han, T., Kloster, B., Cabradilla, C., Blair, D., Zamkoff, K., and Comis, R.: Association of HTLV with AIDS. Proc. Amer. Soc. Clin. Onc. 3:13, 1984. (Oral Presentation) |
| A-7. |
|
Merl, S., Cowan, B., Graziano, S., Ehrlich, G.D., Hubbell, C., Planas, A., Tomar, R., Davey, F., Moore, J., Comis, R., and Poiesz, B.: A quantitative assay for HTLV transformation. Proc. Amer. Soc. Clin. Onc. 3:5, 1984. (Oral Presentation) |
| A-8. |
|
Lehr, B., Ehrlich, G.D., Davey, F., et. al.: HTLV-I associated benign T-cell lymphocytosis. Amer. Soc. Clin. Onc. 4:12, March, 1985. |
| A-9. |
|
Ehrlich, G.D., Lehr, B., Davey, F., Planas, A., Kershner, J., Moore, J., Johnston, L., Davis, B., Halinan, E., Vournakis, J., and Poiesz, B.: Genomic characterization of an HTLV-I subtype isolated from a patient with a benign lymphocytosis. Cold Spring Harbor Laboratory Conference on AIDS. Cold Spring Harbor, NY, May 21-26, 1985. |
| A-10. |
|
Poiesz, B., Ehrlich, G.D., Moore, J.L., Friedman-Kien, A., LaFleur, F., Montagna, R., and Papsidero, L.: Incidence of HTLV-III infection in the semen of AIDS and ARC patients. Clinical Research, 34(2): 529A, April, 1986. (Oral Presentation) |
| A-11. |
|
Poiesz, B., Ehrlich, G.D., Moore, J., et. al.: HTLV-III detection in blood and semen. New York Academy of Sciences Meeting, 1986. (Oral Presentation) |
| A-12. |
|
Kwok, S., Mack., D., Poiesz, B., Ehrlich, G.D., Blair, D., Friedman-Kien, A., and Sninsky, J.: Detection of AIDS viral nucleic acid sequences by enzymatic amplification. International Conference of AIDS, Paris, France, 1986. |
| A-13. |
|
LaFleur, F.L., Friedman-Kien, A.E., Hennessey, N.P., Wernz, J.C., Montagna, R., Ehrlich, G.D., and Poiesz, B.J.: Prevalence of HTLV-III infection in peripheral blood (PB), seminal mononuclear and cell-free semen of ARC and AIDS-associated Kaposi's Sarcoma (KS) patients: Preliminary analysis. International Conference on AIDS. Paris, France, 1986. |
| A-14. |
|
Poiesz, B.J., Ehrlich, G.D., Papsidero, L., Montagna, R., Kwok, S., Mack, D., and Sninsky, J.J.: Methods for the detection of HIV antibodies, antigens and nucleic acids. (Presented at WHO meeting, October 1986, Paris, France). |
| A-15. |
|
Poiesz, B.J., Ehrlich, G.D., Kwok, S. and Sninsky, J.J.: Gene amplification as a tool for detection and analysis of human retroviruses. Amer. Assoc. for Cancer Res. Proceedings, 1987. |
| A-16. |
|
Poiesz, B.J., Ehrlich, G.D., Papsidero, L., Montagna, R., Kwok, S., Sninsky, J., et. al.: Incidence of seronegativity to HIV and HTLV-I in individuals infected with either virus. III International Conference on Acquired Immunodeficiency Syndrome (AIDS), June 1-5, 1987, p. 114. |
| A-17. |
|
Sninsky, J.J., Kowk, S., Mack, D., Ehrlich, G.D., Ullrich, P., Poiesz, B., et. al.: Identification of HIV sequence in DNA extracted directly from peripheral blood lymphocytes and bone marrow using in vitro DNA amplification. III International Conference on Acquired Immunodeficiency Syndrome (AIDS), Washington, D.C., June 1-5, 1987, p 207. (Oral Presentation) |
| A-18. |
|
Mildvan, D., Desjarlais, D., Sotheran, J., Dawson, G., Shonekan, D., Allain, J.P., Kouzi, A.C., Lee, H., Weber, J., Stoneburner, R., Ehrlich, G.D., Poiesz, B.: Prevalence and significance of HTLV-I in a cohort of IV drug users in New York [abstract #4517]. IV International Conference on AIDS, Amsterdam, The Netherlands, June 12-16, 1988. |
| A-19. |
|
Abbott, M.A., Poiesz, B.J., Byrne, B.C., Kwok, S., Sninsky, J.J., Ehrlich, G.D.: Methods for detecting proviral DNA amplified in vitro and their use for analysis of retroviral variants. 21st Adirondacks Molecular Biology and Genetics Conference, Blue Mountain Lake, NY, Sept. 30-Oct. 2, 1988. |
| A-20. |
|
Ehrlich, G.D., Abbott, M.A., Greenberg, S., Bhagavati, S., Sninsky, J.J., Kwok, S., Poiesz, B.J.: Association of human retroviruses with neurological diseases. 21st Adirondacks Molecular Biology and Genetics Conference, Blue Mountain Lake, NY, Sept. 30-Oct. 2, 1988. (Oral Presentation) |
| A-21. |
|
Ehrlich, G.D., Quan, D., Lavigne, K., Sninsky, J.J., Poiesz, B.J.: Simultaneous screening for multiple human retroviruses in risk group individuals via the polymerase chain reaction and liquid hybridization. AAAS Annual Meeting, San Francisco, Jan. 14-19, 1989. (Oral Presentation) |
| A-22. |
|
Ehrlich, G.D., Abbott, M.A., Bhagavati, S., Glaser, J.B., Sliwkowski, M., Sninsky, J.J., Poiesz, B.J.: Detection of anti-HTLV-I Tax antibodies in HTLV-I ELISA negative individuals and TSP/HAM patients: Confirmation of infection by PCR. UCLA Meeting Human Retroviruses, Tamarron CO., Feb. 4-11, 1989. |
| A-23. |
|
Greenberg, S.J., Jacobson, S., Abbott, M.A., Bhagavati, S., McFarlin, D.E., Poiesz, B.J., Waldman, J.A., Ehrlich, G.D.*: Variability of provirus from HTLV-I associated tropical spastic paraparesis and adult T-cell leukemia detected by gene amplification. UCLA Meeting on Human Retroviruses. Tamarron, CO., Feb. 4-11, 1989. |
| A-24. |
|
Greenberg, S.J., Ehrlich, G.D., Abbott, M.A., Hurwitz, B.J., Waldman, T.A., Poiesz, B.J.: Demonstration of retroviral sequences related to human T-cell leukemia/lymphoma virus, Type I in Multiple Sclerosis by gene amplification. 41st Annual Meeting of American Academy of Neurology, Chicago, April 13-14, 1989. (Oral Presentation) |
| A-25. |
|
Poiesz, B.J., Abbott, M.A., Glaser, J.B., Greenberg, S.J., Bhagavati, S., Sninsky, J.J., Kwok, S. and Ehrlich, G.D. Polymerase chain reaction and the detection of human retroviruses. UCLA Meeting, Keystone CO, April 1989. |
| A-26. |
|
Abbott, M.A., Poiesz, B.J., Byrne, B.C., Kwok, S., Sninsky, J.J. and Ehrlich, G.D.: Methods for detecting proviral DNA amplified in vitro and their use for analysis of retroviral variants. UCLA Meeting Human Retroviruses, Tamarron, CO, Feb. 4-11, 1989. |
| A-27. |
|
Poiesz, B.J., Ehrlich, G.D., Papsidero, L., Montagna, R. and the HTLV-I working group: Seroprevalence of HTLV-I in various patient populations. UCLA Meeting Human Retroviruses, Tamarron, CO, Feb. 4-11, 1989. |
| A-28. |
|
Glaser, J., Monnier, J., D'Angelo, K., Drakatos, A., Poiesz, B., Ehrlich, G.D., et al. Prevalence of syphilis, HTLV-I, HTLV-II and HIV-1 among crack and other drug users. 5th International Conference on AIDS, Montreal, Quebec, CANADA; June 4-9, 1989. |
| A-29. |
|
Glaser, J.B., Poiesz, B.J., Sliwkowski, M., Simpkins, H., J.J., Ehrlich, G.D., et al. Anti-HTLV-I Tax ELISA for detection of infection in standard HTLV-I ELISA negative intravenous dru | |