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 The
Center for Genomic Sciences (CGS) is a comprehensive and flexible research
facility designed to investigate a broad range of medically and surgically
relevant problems using cutting-edge molecular genetic and bioinformatics techniques.
CGS is a self-contained research unit of Allegheny-Singer Research
Institute, ASRI, the research arm of Allegheny General Hospital which, in turn, serves as the
tertiary care facility for the entire West Penn Allegheny Health System
The facilities and intellectual infrastructure of CGS provides
a collegial and collaborative academic/clinical environment that promotes interdisciplinary
research grounded in the fundamental concepts of modern functional
genomics. The Center fosters the development of surgeon-scientists,
physician-scientists and biomedical researchers throughout the institution
and the Pittsburgh
area by actively working to develop partnerships among teams of individuals
with diverse scientific, clinical, computational and engineering
backgrounds. CGS scientists study genetic and evolutionary phenomena that
impact human health from a top-down approach. This is accomplished by the
use of global research tools which permit imaging of entire genomes and expressomes simultaneously, as opposed to narrowly
investigating a single gene in isolation from its environment. This is the
molecular biological equivalent of studying a symphony from a conductor's
score instead of just listening to the second oboe to try to discern what
the composer had in mind. This approach to learning and understanding is
applied to viral and bacterial pathogens as well as to their human hosts.
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