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Natalia Luisa Hiller, Ph.D.
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B.S.
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Biology, Pomona College, Claremont, California
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Ph.D.
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Immunology and Microbial Pathogenesis, Northwestern University
Medical School, Chicago, Illinois
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Research Interests
- Molecular Pathogenesis
- Bioinformatics
Current Project
- Study the interactions between
microorganisms and their hosts using comparative genomics.
Honor & Awards
- Predoctoral Fellowship,
American Heart Association, Chicago, IL
- Predoctoral Fellowship (top
2.8%), American Heart Association, Chicago, IL
- Northwestern University
Scholar Award, Chicago, IL
- Northwestern University
Scholar Award, Chicago, IL
- Alfred P. Sloan Foundation,
Gordon Conference, Il Ciocceo, Italy
- Travel Award, Northwestern
University, Chicago, IL
- Award for Best Student Poster,
Northwestern Pathology Retreat, Chicago, IL
- Center for Genetic Medicine
Travel Award, Northwestern University, Chicago, IL
- ASTMH Award for Scientific
Excellence, Molecular Parasitology Mtg., Woods Hole, MA
Professional Memberships
- American Society for
Microbiology
- American Association for the
Advancement of Science
Publications
Lauer S, VanWye J, Harrison T, McManus H,
Samuel BU, Hiller NL, Mohandas N, Haldar K. Vacuolar uptake of host
components, and a role for cholesterol and sphingomyelin in malarial
infection. EMBO J 19;14:3556-3564, 2000.
Haldar K, Samuel BU, Mohandas N, Harrison T, Hiller NL. Erythrocytic
vacuolar rafts induced by malaria parasites. Curr Opin Hematol 8;2:92-97,
2001.
Haldar K, Samuel BU, Mohandas N, Harrison T, Hiller NL. Transport
mechanisms in plasmodium-infected erythrocytes: Lipid rafts and a
tubovesicular network. Int J Parasitol 31;12:1393-1401, 2001.
Haldar K, Mohandas N, Samuel BU, Harrison T, Hiller NL, Akompong T,
Cheresh P. Protein and lipid trafficking induced in erythrocytes infected by
malaria parasites. Cell Microbiol 4;7:383-395, 2002.
Hiller NL, Akompong T, Morrow JS, Holder AA, Haldar K. Identification
of a stomatin orthologue in vacuoles induced in human erythrocytes by malaria
parasites: A role for microbial raft-proteins in apicomplexan vacuole
biogenesis. J Biol Chem 278;48:48413-48421, 2003.
Hiller NL, Bhattacharjee S, van Ooij C, Liolios K, Harrison T,
Lopez-Estrano C, Haldar K. A host-targeting signal in virulence proteins
reveals a secretome in malarial infection. Science 306;5703:1934-1937, 2004.
This article was highlighted in Nature Reviews Microbiology 3, 97-98, 2005.
Haldar K, Hiller NL, van Ooij C, Bhattacharjee S. Plasmodium parasite
proteins and the infected erythrocyte. Trends Parasitol 21;9:402-403, 2005.
Murphy SC, Hiller NL, Harrison T, Lomasney JW, Mohandas N, Haldar K.
Lipid rafts and malaria parasite infection of erythrocytes. Mol Membr Biol
23;1:81-88, 2006.
Bhattacharjee S*, Hiller NL*, Liolios K, Win J, Kanneganti TD, Young
C, Kamoun S, Haldar K. The malarial host-targeting signal is conserved in the
Irish potato famine pathogen. PLOS Pathogens 2;5:e50, 2006. * Equally
contributing authors. This article was selected for Editor's Choice in
Science 312; 5780: 1574, 2006.
Haldar K, Kamoun S, Hiller NL, Bhattacharje S, van Ooij C. Common infection
strategies of pathogenic eukaryotes. Nat Rev Microbiol 4;12:922-931, 2006.
Buchinsky FJ, Forbes ML, Hayes JD, Shen K, Ezzo S, Compliment J, Hogg J, Hiller
NL, Hu FZ, Post JC, Ehrlich GD. Virulence phenotypes of low-passage
clinical isolates of nontypeable Haemophilus influenzae assessed using
the chinchilla laniger model of otitis media. BMC Microbiol 7:56, 2007.
Hiller NL, Janto B, Hogg JS, Boissy R, Yu S, Powell E, Keefe R,
Ehrlich NE, Shen K, Hayes J, Barbadora K, Klimke W, Dernovoy D, Tatusova T,
Parkhill J, Bentley SD, Post JC, Ehrlich GD, Hu FZ. Comparative genomic
analyses of seventeen Streptococcus pneumoniae strains: Insights into
the pneumococcal supragenome. J Bacteriol 189(22):8186-8195, 2007.
Pollard AM, Onatolu KN, Hiller
L, Haldar K, Knoll LJ.
Highly polymorphic family of glycosylphosphatidylinositol-anchored
surface antigens with evidence of developmental regulation in Toxoplasma
gondii. Infect Immun
76;1:103-110, 2007.
Forbes ML, Horsey E, Hiller NL,
Buchinsky FJ, Hayes JD, Compliment JM, Hillman T, Ezzo S, Shen K, Keefe R,
Barbadora K, Post JC, Hu FZ, Ehrlich GD. Strain-specific virulence phenotypes of Streptococcus
pneumoniae assessed using the Chinchilla laniger model of otitis
media. PLoS One 3;4:e1969, 2008.
van Ooij C, Tamez P,
Bhattacharjee S, Hiller NL, Harrison T, Liolios K, Kooij T, Ramesar J,
Balu B, Adams J, Waters A, Janse C, Haldar K. The malaria secretome: From algorithms to essential function in blood stage
infection. PLoS Pathog
4(6):e1000084, 2008.
Ehrlich GD, Hiller NL, Hu
FZ. What makes pathogens
pathogenic. Genome Biol 9;6:225,
2008.
Tamez PA, Bhattacharjee S, van
Ooij C, Hiller NL, LlinVs M, Balu B, Adams JH, Haldar K. An erythrocyte vesicle protein
exported by the malaria parasite promotes tubovesicular lipid import from the
host cell surface. PLoS Pathog
4;8:e1000118, 2008.
Selected Presentations and Abstracts
N. Luisa Hiller, T. Akompong, C. Olson, I.T. Ling, A.A.
Holder, K. Haldar. Cholesterol Rafts in Apical Organelles of Plasmodium
falciparum. American Society of Hematology, Philadelphia, PA, 2002,
Poster.
N. Luisa Hiller, T. Akompong, C. Olson, I.T. Ling, A.A. Holder, K.
Haldar. The Apical Organelles of the Malaria Parasite Contain
Cholesterol-Rich Detergent Resistant Membranes Which May Play a Role in the
Intraerythrocytic Development. Gordon Red Cell Conference, Il Ciocco, Italy,
2003, Poster.
N. Luisa Hiller, Irene Ling, Jon S. Morrow, Anthony A. Holder and
Kasturi Haldar. A Malarial Homologue of Stomatin: Implications for Parasite
Vacuolar Development. Molecular Parasitology Meeting, Woods Hole, MA, 2003.
N. Luisa Hiller, Travis Harrison, Sean Murphy, Benjamin Samuel, Thomas
Akompong, Heidi Hamm, Narla Mohandas, Anthony Holder, Jon Morrow, Jon
Lomasney, and Kasturi Haldar. Raft-based, erythrocyte G protein signaling in
malarial infection. American Society of Hematology, San Diego, CA, 2003,
Poster.
N. Luisa Hiller, Thomas Akompong, Jon S. Morrow, Anthony A. Holder,
and Kasturi Haldar. A Malarial Homologue of Stomatin: Implications for Parasite
Vacuolar Development. Molecular Approaches to Malaria Meeting, Lorne,
Australia, 2004. Presented talk and poster.
N. Luisa Hiller, Christiaan van Ooij, Souvik Batthacharjee,
Konstantinos Liolios, Travis Harrison, Carlos Lopez-Estrano and Kasturi Haldar.
A secretome linked to targeting parasite proteins to the erythrocyte in
malarial infection. Molecular Parasitology Meeting, Woods Hole, MA and ASTMH
Meeting, Miami Beach, FL, 2004.
Sean C Murphy, N. Luisa Hiller, Paul Chung, S.N. Prasana Murthy, Alex
Brown, Heidi E Hamm, Jon W. Lomasney, Kasturi Haldar. Multiple signaling
intermediates regulate invasion of human erythrocytes by Plasmodium
falciparum. Molecular Parasitology Meeting, Woods Hole, MA, 2005.
Souvik Bhattacharjee, N. Luisa Hiller, Konstantinos Liolios, Sophien
Kamoun, Kasturi Haldar. Involvement of the P. falciparum host-targeting
signal in a eukaryotic secretion system shared with plant pathogenic
oomycetes. Molecular Parasitology Meeting, Woods Hole, MA, 2005.
Christiaan van Ooij, N. Luisa Hiller, Souvik Bhattacharjee, Travis
Harrison, Konstantinos Liolios, Laura Knoll, Elizabeth Glass, Natalia
Maltsev, Joe Win, Thirumala-Devi Kanneganti, Carolyn Young, Sophien Kamoun
and Kasturi Haldar. Conservation of pathogenic secretion signals of eukaryotic
microbes used to access animal and plant hosts. Great Lakes Regional Center
of Excellence for Biodefense and Emerging Infectious Disease Research, Hilton
Head, SC, 2005.
N. Luisa Hiller, Justin Hogg, Benjamin Janto, Jennifer Bennett, Rory
Eutsey, Azad Ahmed, Garth Ehrlich, Fen Z. Hu. Identification of a
host-interacting protein family in Haemophilus influenzae. 107th
General Meeting of the American Society for Microbiology, Toronto, Canada,
2007, Poster.
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